Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 79705
MIM: 610986
HGNC: 18608
Ensembl: ENSG00000154237
Variants:
dbSNP: 79705
ClinVar: 79705
TCGA: ENSG00000154237
COSMIC: LRRK1
RNA/Proteins
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37558661 | 2023 | Structure and regulation of full-length human leucine-rich repeat kinase 1. | 0 |
| 37558661 | 2023 | Structure and regulation of full-length human leucine-rich repeat kinase 1. | 0 |
| 34798323 | 2022 | Broadening the phenotype of LRRK1 mutations - Features of malignant osteopetrosis and optic nerve atrophy with intrafamilial variable expressivity. | 4 |
| 36040231 | 2022 | PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the CORB GTPase domain. | 4 |
| 34798323 | 2022 | Broadening the phenotype of LRRK1 mutations - Features of malignant osteopetrosis and optic nerve atrophy with intrafamilial variable expressivity. | 4 |
| 36040231 | 2022 | PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the CORB GTPase domain. | 4 |
| 33459343 | 2021 | Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms. | 22 |
| 33459343 | 2021 | Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms. | 22 |
| 29812962 | 2018 | Genetic Analysis of LRRK1 and LRRK2 Variants in Essential Tremor Patients. | 6 |
| 29812962 | 2018 | Genetic Analysis of LRRK1 and LRRK2 Variants in Essential Tremor Patients. | 6 |
| 27829680 | 2017 | Identification of a novel LRRK1 mutation in a family with osteosclerotic metaphyseal dysplasia. | 16 |
| 27829680 | 2017 | Identification of a novel LRRK1 mutation in a family with osteosclerotic metaphyseal dysplasia. | 16 |
| 27055475 | 2016 | Identification of biallelic LRRK1 mutations in osteosclerotic metaphyseal dysplasia and evidence for locus heterogeneity. | 24 |
| 27055475 | 2016 | Identification of biallelic LRRK1 mutations in osteosclerotic metaphyseal dysplasia and evidence for locus heterogeneity. | 24 |
| 25413345 | 2015 | LRRK1-phosphorylated CLIP-170 regulates EGFR trafficking by recruiting p150Glued to microtubule plus ends. | 17 |
Citation
Dessen P
LRRK1 (leucine rich repeat kinase 1)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/68666/lrrk1-(leucine-rich-repeat-kinase-1)
