LRRTM3 (leucine rich repeat transmembrane neuronal 3)

2014-11-01  

Identity

HGNC
LRRTM3
LOCATION
10q21.3
LOCUSID
347731
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 347731
MIM: 610869
HGNC: 19410
Ensembl: ENSG00000198739

Variants:

dbSNP: 347731
ClinVar: 347731
TCGA: ENSG00000198739
COSMIC: LRRTM3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198739ENST00000361320Q86VH5

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuronal SystemREACTOMER-HSA-112316
Protein-protein interactions at synapsesREACTOMER-HSA-6794362
Interactions of neurexins and neuroligins at synapsesREACTOMER-HSA-6794361

References

Pubmed IDYearTitleCitations
244630502014Association of LRRTM3 polymorphisms with late-onset Alzheimer's disease in Han Chinese.7
244630502014Association of LRRTM3 polymorphisms with late-onset Alzheimer's disease in Han Chinese.7
237502062013LRRTM3 interacts with APP and BACE1 and has variants associating with late-onset Alzheimer's disease (LOAD).9
237502062013LRRTM3 interacts with APP and BACE1 and has variants associating with late-onset Alzheimer's disease (LOAD).9
223931662012Effect of genetic variation in LRRTM3 on risk of Alzheimer disease.12
227109092012LRRTM3 is dispensable for amyloid-β production in mice.0
223931662012Effect of genetic variation in LRRTM3 on risk of Alzheimer disease.12
227109092012LRRTM3 is dispensable for amyloid-β production in mice.0
215980202011Alpha T-catenin (CTNNA3): a gene in the hand is worth two in the nest.8
215980202011Alpha T-catenin (CTNNA3): a gene in the hand is worth two in the nest.8
206782492010Polymorphisms in leucine-rich repeat genes are associated with autism spectrum disorder susceptibility in populations of European ancestry.25
206782492010Polymorphisms in leucine-rich repeat genes are associated with autism spectrum disorder susceptibility in populations of European ancestry.25
191052032009An association analysis of Alzheimer disease candidate genes detects an ancestral risk haplotype clade in ACE and putative multilocus association between ACE, A2M, and LRRTM3.18
191052032009An association analysis of Alzheimer disease candidate genes detects an ancestral risk haplotype clade in ACE and putative multilocus association between ACE, A2M, and LRRTM3.18
191052032009An association analysis of Alzheimer disease candidate genes detects an ancestral risk haplotype clade in ACE and putative multilocus association between ACE, A2M, and LRRTM3.18

Citation

Dessen P

LRRTM3 (leucine rich repeat transmembrane neuronal 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/68673/lrrtm3-(leucine-rich-repeat-transmembrane-neuronal-3)