LRSAM1 (leucine rich repeat and sterile alpha motif containing 1)

2014-11-01  

Identity

HGNC
LOCATION
9q33.3
LOCUSID
ALIAS
CMT2P,RIFLE,TAL
FUSION GENES

Other Information

Locus ID:

NCBI: 90678
MIM: 610933
HGNC: 25135
Ensembl: ENSG00000148356

Variants:

dbSNP: 90678
ClinVar: 90678
TCGA: ENSG00000148356
COSMIC: LRSAM1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000148356ENST00000300417Q6UWE0
ENSG00000148356ENST00000300417A0A024R870
ENSG00000148356ENST00000323301Q6UWE0
ENSG00000148356ENST00000323301A0A024R870
ENSG00000148356ENST00000373322Q6UWE0
ENSG00000148356ENST00000373322A0A024R870
ENSG00000148356ENST00000373324Q6UWE0

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
383308022024A novel mutation in the LRSAM1 gene in a family with early onset autosomal dominant Charcot-Marie-Tooth type 2P.0
383308022024A novel mutation in the LRSAM1 gene in a family with early onset autosomal dominant Charcot-Marie-Tooth type 2P.0
358424402022C698R mutation in Lrsam1 gene impairs nerve regeneration in a CMT2P mouse model.1
359222142022[Novel MFN2, BSCL2 and LRSAM1 variants in a cohort of Chinese patients with Charcot-Marie-Tooth disease].0
358424402022C698R mutation in Lrsam1 gene impairs nerve regeneration in a CMT2P mouse model.1
359222142022[Novel MFN2, BSCL2 and LRSAM1 variants in a cohort of Chinese patients with Charcot-Marie-Tooth disease].0
332072622021LRSAM1 E3 ubiquitin ligase promotes proteasomal clearance of E6-AP protein.1
334140562021Location matters - Genotype-phenotype correlation in LRSAM1 mutations associated with rare Charcot-Marie-Tooth neuropathy CMT2P.1
332072622021LRSAM1 E3 ubiquitin ligase promotes proteasomal clearance of E6-AP protein.1
334140562021Location matters - Genotype-phenotype correlation in LRSAM1 mutations associated with rare Charcot-Marie-Tooth neuropathy CMT2P.1
318529842020Identification of novel pathogenic copy number variations in Charcot-Marie-Tooth disease.4
319825662020Ubiquitin ligase LRSAM1 suppresses neurodegenerative diseases linked aberrant proteins induced cell death.1
318529842020Identification of novel pathogenic copy number variations in Charcot-Marie-Tooth disease.4
319825662020Ubiquitin ligase LRSAM1 suppresses neurodegenerative diseases linked aberrant proteins induced cell death.1
308268592019LRSAM1 E3 ubiquitin ligase: molecular neurobiological perspectives linked with brain diseases.5

Citation

Dessen P

LRSAM1 (leucine rich repeat and sterile alpha motif containing 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/68675/lrsam1-(leucine-rich-repeat-and-sterile-alpha-motif-containing-1)