Identity
HGNC
LOCATION
6p25.1
LOCUSID
ALIAS
C6orf149,CGI-203,COXPD19,ISD11
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 57128
MIM: 613311
HGNC: 21365
Ensembl: ENSG00000214113
Variants:
dbSNP: 57128
ClinVar: 57128
TCGA: ENSG00000214113
COSMIC: LYRM4
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Metabolism | REACTOME | R-HSA-1430728 |
| Mitochondrial iron-sulfur cluster biogenesis | REACTOME | R-HSA-1362409 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 31664822 | 2019 | Structure of the Human ACP-ISD11 Heterodimer. | 4 |
| 31664822 | 2019 | Structure of the Human ACP-ISD11 Heterodimer. | 4 |
| 29983374 | 2018 | Architectural Features of Human Mitochondrial Cysteine Desulfurase Complexes from Crosslinking Mass Spectrometry and Small-Angle X-Ray Scattering. | 9 |
| 29983374 | 2018 | Architectural Features of Human Mitochondrial Cysteine Desulfurase Complexes from Crosslinking Mass Spectrometry and Small-Angle X-Ray Scattering. | 9 |
| 28271877 | 2017 | The N-Terminus of Iron-Sulfur Cluster Assembly Factor ISD11 Is Crucial for Subcellular Targeting and Interaction with l-Cysteine Desulfurase NFS1. | 9 |
| 28634302 | 2017 | Structure of human Fe-S assembly subcomplex reveals unexpected cysteine desulfurase architecture and acyl-ACP-ISD11 interactions. | 79 |
| 28271877 | 2017 | The N-Terminus of Iron-Sulfur Cluster Assembly Factor ISD11 Is Crucial for Subcellular Targeting and Interaction with l-Cysteine Desulfurase NFS1. | 9 |
| 28634302 | 2017 | Structure of human Fe-S assembly subcomplex reveals unexpected cysteine desulfurase architecture and acyl-ACP-ISD11 interactions. | 79 |
| 27427956 | 2016 | The Eukaryotic-Specific ISD11 Is a Complex-Orphan Protein with Ability to Bind the Prokaryotic IscS. | 5 |
| 27519411 | 2016 | Architecture of the Human Mitochondrial Iron-Sulfur Cluster Assembly Machinery. | 15 |
| 27427956 | 2016 | The Eukaryotic-Specific ISD11 Is a Complex-Orphan Protein with Ability to Bind the Prokaryotic IscS. | 5 |
| 27519411 | 2016 | Architecture of the Human Mitochondrial Iron-Sulfur Cluster Assembly Machinery. | 15 |
| 26342079 | 2015 | Mapping Key Residues of ISD11 Critical for NFS1-ISD11 Subcomplex Stability: IMPLICATIONS IN THE DEVELOPMENT OF MITOCHONDRIAL DISORDER, COXPD19. | 13 |
| 26342079 | 2015 | Mapping Key Residues of ISD11 Critical for NFS1-ISD11 Subcomplex Stability: IMPLICATIONS IN THE DEVELOPMENT OF MITOCHONDRIAL DISORDER, COXPD19. | 13 |
| 23814038 | 2013 | Mutations in LYRM4, encoding iron-sulfur cluster biogenesis factor ISD11, cause deficiency of multiple respiratory chain complexes. | 50 |
Citation
Dessen P
LYRM4 (LYR motif containing 4)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/68728/lyrm4-(lyr-motif-containing-4)
