MC5R (melanocortin 5 receptor)

2014-11-01  

Identity

HGNC
LOCATION
18p11.21
LOCUSID
ALIAS
MC2

Other Information

Locus ID:

NCBI: 4161
MIM: 600042
HGNC: 6933
Ensembl: ENSG00000176136

Variants:

dbSNP: 4161
ClinVar: 4161
TCGA: ENSG00000176136
COSMIC: MC5R

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000176136ENST00000324750P33032
ENSG00000176136ENST00000589410P33032

Expression (GTEx)

0
1

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
337657502021Evaluation of perilipin 2 and melanocortin 5 receptor serum levels with sebogenesis in acne vulgaris patients.3
337657502021Evaluation of perilipin 2 and melanocortin 5 receptor serum levels with sebogenesis in acne vulgaris patients.3
307395302019ARPE-19-derived VEGF-containing exosomes promote neovascularization in HUVEC: the role of the melanocortin receptor 5.23
307395302019ARPE-19-derived VEGF-containing exosomes promote neovascularization in HUVEC: the role of the melanocortin receptor 5.23
283960172017Cell surface targeting of the Melanocortin 5 Receptor (MC5R) requires serine-rich terminal motifs.4
283960172017Cell surface targeting of the Melanocortin 5 Receptor (MC5R) requires serine-rich terminal motifs.4
258608012015Melanocortins contribute to sequential differentiation and enucleation of human erythroblasts via melanocortin receptors 1, 2 and 5.11
262236772015Expression of melanocortin receptors in human endometrium.5
258608012015Melanocortins contribute to sequential differentiation and enucleation of human erythroblasts via melanocortin receptors 1, 2 and 5.11
262236772015Expression of melanocortin receptors in human endometrium.5
234141132013Molecular characterization of human melanocortin-5 receptor ligand-receptor interaction.3
234141132013Molecular characterization of human melanocortin-5 receptor ligand-receptor interaction.3
228719662012Melanocortin 5 receptor signaling and internalization: role of MAPK/ERK pathway and β-arrestins 1/2.8
228719662012Melanocortin 5 receptor signaling and internalization: role of MAPK/ERK pathway and β-arrestins 1/2.8
216020332011A melanocortin receptor 1 and 5 antagonist inhibits sebaceous gland differentiation and the production of sebum-specific lipids.10

Citation

Dessen P

MC5R (melanocortin 5 receptor)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/68837/mc5r-(melanocortin-5-receptor)