MDFIC (MyoD family inhibitor domain containing)

2014-11-01  

Identity

HGNC
MDFIC
LOCATION
7q31.1
LOCUSID
29969
ALIAS
HIC,MDFIC1

Other Information

Locus ID:

NCBI: 29969
MIM: 614511
HGNC: 28870
Ensembl: ENSG00000135272

Variants:

dbSNP: 29969
ClinVar: 29969
TCGA: ENSG00000135272
COSMIC: MDFIC

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135272ENST00000257724J3KN13
ENSG00000135272ENST00000393486Q9P1T7
ENSG00000135272ENST00000423503C9J104
ENSG00000135272ENST00000427207H7BZY3
ENSG00000135272ENST00000431629H7C4B9
ENSG00000135272ENST00000448022C9J104
ENSG00000135272ENST00000498196C9J784

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
375903482023MyoD-family inhibitor proteins act as auxiliary subunits of Piezo channels.6
375903482023MyoD-family inhibitor proteins act as auxiliary subunits of Piezo channels.6
352353412022Pathogenic variants in MDFIC cause recessive central conducting lymphatic anomaly with lymphedema.12
352353412022Pathogenic variants in MDFIC cause recessive central conducting lymphatic anomaly with lymphedema.12
324574532020Opposite Roles of the JMJD1A Interaction Partners MDFI and MDFIC in Colorectal Cancer.17
324574532020Opposite Roles of the JMJD1A Interaction Partners MDFI and MDFIC in Colorectal Cancer.17
282233522017Cross-talk between the glucocorticoid receptor and MyoD family inhibitor domain-containing protein provides a new mechanism for generating tissue-specific responses to glucocorticoids.14
282233522017Cross-talk between the glucocorticoid receptor and MyoD family inhibitor domain-containing protein provides a new mechanism for generating tissue-specific responses to glucocorticoids.14
264695492015I-mfa domain proteins specifically interact with HTLV-1 Tax and repress its transactivating functions.9
264695492015I-mfa domain proteins specifically interact with HTLV-1 Tax and repress its transactivating functions.9
214019182011Intermolecular masking of the HIV-1 Rev NLS by the cellular protein HIC: novel insights into the regulation of Rev nuclear import.15
214019182011Intermolecular masking of the HIV-1 Rev NLS by the cellular protein HIC: novel insights into the regulation of Rev nuclear import.15
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
204176162010Human I-mfa domain proteins specifically interact with KSHV LANA and affect its regulation of Wnt signaling-dependent transcription.15
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78

Citation

Dessen P

MDFIC (MyoD family inhibitor domain containing)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/68859/mdfic-(myod-family-inhibitor-domain-containing)