METTL5 (methyltransferase 5, N6-adenosine)

2014-11-01  

Identity

HGNC
LOCATION
2q31.1
LOCUSID
ALIAS
HSPC133,MRT72

Other Information

Locus ID:

NCBI: 29081
MIM: 618628
HGNC: 25006
Ensembl: ENSG00000138382

Variants:

dbSNP: 29081
ClinVar: 29081
TCGA: ENSG00000138382
COSMIC: METTL5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138382ENST00000260953Q9NRN9
ENSG00000138382ENST00000308099E7EMN2
ENSG00000138382ENST00000392640Q9NRN9
ENSG00000138382ENST00000409340B8ZZY8
ENSG00000138382ENST00000409837B8ZZE3
ENSG00000138382ENST00000409965Q9NRN9
ENSG00000138382ENST00000410097B8ZZC8
ENSG00000138382ENST00000442181H7C0M7
ENSG00000138382ENST00000537825H0YFV5
ENSG00000138382ENST00000538491F5H4E8

Expression (GTEx)

0
10
20
30
40
50
60
70

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
386131572024The m6A methyltransferase METTL5 promotes neutrophil extracellular trap network release to regulate hepatocellular carcinoma progression.1
386639142024Biological significance of METTL5 in atherosclerosis: comprehensive analysis of single-cell and bulk RNA sequencing data.0
386131572024The m6A methyltransferase METTL5 promotes neutrophil extracellular trap network release to regulate hepatocellular carcinoma progression.1
386639142024Biological significance of METTL5 in atherosclerosis: comprehensive analysis of single-cell and bulk RNA sequencing data.0
363697912023Knockdown of METTL5 inhibits the Myc pathway to downregulate PD-L1 expression and inhibits immune escape of hepatocellular carcinoma cells.6
366024282023METTL5 stabilizes c-Myc by facilitating USP5 translation to reprogram glucose metabolism and promote hepatocellular carcinoma progression.21
363697912023Knockdown of METTL5 inhibits the Myc pathway to downregulate PD-L1 expression and inhibits immune escape of hepatocellular carcinoma cells.6
366024282023METTL5 stabilizes c-Myc by facilitating USP5 translation to reprogram glucose metabolism and promote hepatocellular carcinoma progression.21
351666442022The potential role of methyltransferase-like 5 in deficient mismatch repair of uterine corpus endometrial carcinoma.6
363054502022Three Afghani siblings with a novel homozygous variant and further delineation of the clinical features of METTL5 related intellectual disability syndrome.1
351666442022The potential role of methyltransferase-like 5 in deficient mismatch repair of uterine corpus endometrial carcinoma.6
363054502022Three Afghani siblings with a novel homozygous variant and further delineation of the clinical features of METTL5 related intellectual disability syndrome.1
334289442021Enzymatic characterization of three human RNA adenosine methyltransferases reveals diverse substrate affinities and reaction optima.18
345175472021Analysis of the role of METTL5 as a hub gene in lung adenocarcinoma based on a weighted gene co-expression network.5
334289442021Enzymatic characterization of three human RNA adenosine methyltransferases reveals diverse substrate affinities and reaction optima.18

Citation

Dessen P

METTL5 (methyltransferase 5, N6-adenosine)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/68925