METTL6 (methyltransferase 6, methylcytidine)

2014-11-01  

Identity

HGNC
LOCATION
3p25.1
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 131965
MIM: 618903
HGNC: 28343
Ensembl: ENSG00000206562

Variants:

dbSNP: 131965
ClinVar: 131965
TCGA: ENSG00000206562
COSMIC: METTL6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000206562ENST00000383789Q8TCB7
ENSG00000206562ENST00000383790Q8TCB7
ENSG00000206562ENST00000443029Q8TCB7
ENSG00000206562ENST00000450816B4DDX3
ENSG00000206562ENST00000453819H7C3H9
ENSG00000206562ENST00000458728H7C1L4
ENSG00000206562ENST00000598878M0R0W0

Expression (GTEx)

0
5
10
15

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
349221972022Structural basis for METTL6-mediated m3C RNA methylation.3
349221972022Structural basis for METTL6-mediated m3C RNA methylation.3
342685572021Mutually exclusive substrate selection strategy by human m3C RNA transferases METTL2A and METTL6.19
348624642021Crystal structure of human METTL6, the m(3)C methyltransferase.5
342685572021Mutually exclusive substrate selection strategy by human m3C RNA transferases METTL2A and METTL6.19
348624642021Crystal structure of human METTL6, the m(3)C methyltransferase.5
329236172020METTL6 is a tRNA m(3)C methyltransferase that regulates pluripotency and tumor cell growth.41
329236172020METTL6 is a tRNA m(3)C methyltransferase that regulates pluripotency and tumor cell growth.41
286557672017Three distinct 3-methylcytidine (m(3)C) methyltransferases modify tRNA and mRNA in mice and humans.107
286557672017Three distinct 3-methylcytidine (m(3)C) methyltransferases modify tRNA and mRNA in mice and humans.107

Citation

Dessen P

METTL6 (methyltransferase 6, methylcytidine)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/68926/mettl6-(methyltransferase-6-methylcytidine)