MGST3 (microsomal glutathione S-transferase 3)

2014-11-01  

Identity

HGNC
LOCATION
1q24.1
LOCUSID
ALIAS
GST-III
FUSION GENES

Other Information

Locus ID:

NCBI: 4259
MIM: 604564
HGNC: 7064
Ensembl: ENSG00000143198

Variants:

dbSNP: 4259
ClinVar: 4259
TCGA: ENSG00000143198
COSMIC: MGST3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143198ENST00000367883Q5VV89
ENSG00000143198ENST00000367884O14880
ENSG00000143198ENST00000367884A0A024R8Z1
ENSG00000143198ENST00000367885Q5VV89
ENSG00000143198ENST00000367888Q5VV87
ENSG00000143198ENST00000367889O14880
ENSG00000143198ENST00000367889A0A024R8Z1
ENSG00000143198ENST00000627653Q5VV89

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Glutathione metabolismKEGGko00480
Metabolism of xenobiotics by cytochrome P450KEGGko00980
Drug metabolism - cytochrome P450KEGGko00982
Glutathione metabolismKEGGhsa00480
Metabolism of xenobiotics by cytochrome P450KEGGhsa00980
Drug metabolism - cytochrome P450KEGGhsa00982
Chemical carcinogenesisKEGGhsa05204
Chemical carcinogenesisKEGGko05204
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase II conjugationREACTOMER-HSA-156580
Glutathione conjugationREACTOMER-HSA-156590
Aflatoxin activation and detoxificationREACTOMER-HSA-5423646
Platinum drug resistanceKEGGko01524
Platinum drug resistanceKEGGhsa01524
Fluid shear stress and atherosclerosisKEGGko05418
Fluid shear stress and atherosclerosisKEGGhsa05418

References

Pubmed IDYearTitleCitations
252804732014Joint genetic analysis of hippocampal size in mouse and human identifies a novel gene linked to neurodegenerative disease.25
252804732014Joint genetic analysis of hippocampal size in mouse and human identifies a novel gene linked to neurodegenerative disease.25
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
190646102009Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation.16
193430462009Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.4
195361752009Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study.32
190646102009Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation.16
193430462009Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.4
195361752009Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study.32

Citation

Dessen P

MGST3 (microsomal glutathione S-transferase 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/68971/mgst3