PRCC (papillary renal cell carcinoma)
1999-01-01 François Desangles , Jean-Loup Huret AffiliationLaboratoire de Biologie, Hopital du Val de Grace, 75230 Paris, France
Identity
HGNC
LOCATION
1q23.1
IMAGE
LEGEND
Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics
LOCUSID
ALIAS
RCCP1,TPRC
FUSION GENES
DNA/RNA
Description
cDNA of 2039 bp
Transcription
1989 bp RNA; coding sequence: CDS 191...1666
Proteins
Description
491 amino acids; 52 kDa; proline/leucine/glycine rich domain of 150 amino acids in N-term
Expression
wide; in the fetus and in the adult
Homology
none is known
Implicated in
Entity name
t(X;1)(p11.2;q21.2) in renal cell carcinoma --> PRCC /< CC: TXT: TFE3 ID: 86 >
Disease
t(X;1) is a very rare subtype of papillary renal cell carcinoma
Prognosis
overall 5-yr survival rate around 85%
Hybrid gene
5 PRCC- 3 TFE3; variable breakpoint in PRCC; breakpoint in the 1st intron of TFE3
Fusion protein
N-term PRCC with the proline rich sequence fused to most of TFE3, including the ; the reciprocal TFE3-PRCC is expressed; it is to be noted that the normal TFE3 transcript is lost in female patients.
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 8872474 | 1996 | The t(X;1)(p11.2;q21.2) translocation in papillary renal cell carcinoma fuses a novel gene PRCC to the TFE3 transcription factor gene. | Sidhar SK et al |
| 8986805 | 1996 | Fusion of the transcription factor TFE3 gene to a novel gene, PRCC, in t(X;1)(p11;q21)-positive papillary renal cell carcinomas. | Weterman MA et al |
Other Information
Locus ID:
NCBI: 5546
MIM: 179755
HGNC: 9343
Ensembl: ENSG00000143294
Variants:
dbSNP: 5546
ClinVar: 5546
TCGA: ENSG00000143294
COSMIC: PRCC
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000143294 | ENST00000271526 | Q92733 |
| ENSG00000143294 | ENST00000271526 | A0A0S2Z456 |
| ENSG00000143294 | ENST00000454659 | H0Y679 |
| ENSG00000143294 | ENST00000526188 | H0YE12 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 33019842 | 2021 | PRCC-TFE3 fusion-mediated PRKN/parkin-dependent mitophagy promotes cell survival and proliferation in PRCC-TFE3 translocation renal cell carcinoma. | 13 |
| 33019842 | 2021 | PRCC-TFE3 fusion-mediated PRKN/parkin-dependent mitophagy promotes cell survival and proliferation in PRCC-TFE3 translocation renal cell carcinoma. | 13 |
| 28949976 | 2017 | PRCC-TFE3 dual-fusion FISH assay: A new method for identifying PRCC-TFE3 renal cell carcinoma in paraffin-embedded tissue. | 10 |
| 28949976 | 2017 | PRCC-TFE3 dual-fusion FISH assay: A new method for identifying PRCC-TFE3 renal cell carcinoma in paraffin-embedded tissue. | 10 |
| 19422821 | 2009 | The renal cell carcinoma-associated oncogenic fusion protein PRCCTFE3 provokes p21 WAF1/CIP1-mediated cell cycle delay. | 11 |
| 19422821 | 2009 | The renal cell carcinoma-associated oncogenic fusion protein PRCCTFE3 provokes p21 WAF1/CIP1-mediated cell cycle delay. | 11 |
Citation
François Desangles ; Jean-Loup Huret
PRCC (papillary renal cell carcinoma)
Atlas Genet Cytogenet Oncol Haematol. 1999-01-01
Online version: http://atlasgeneticsoncology.org/gene/69/prcc
