Identity
HGNC
LOCATION
11p11.2
LOCUSID
ALIAS
CDC42GAP,RHOGAP,RHOGAP1,p50rhoGAP
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 392
MIM: 602732
HGNC: 673
Ensembl: ENSG00000175220
Variants:
dbSNP: 392
ClinVar: 392
TCGA: ENSG00000175220
COSMIC: ARHGAP1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000175220 | ENST00000311956 | Q07960 |
| ENSG00000175220 | ENST00000525488 | E9PNR6 |
| ENSG00000175220 | ENST00000528837 | H0YE29 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Signal Transduction | REACTOME | R-HSA-162582 |
| Signaling by Rho GTPases | REACTOME | R-HSA-194315 |
| Rho GTPase cycle | REACTOME | R-HSA-194840 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38740643 | 2024 | Structural basis for the distinct roles of non-conserved Pro116 and conserved Tyr124 of BCH domain of yeast p50RhoGAP. | 0 |
| 38755445 | 2024 | Early gastric cancer with RhoGAP fusion is linked to frequent nodal metastasis and a part of microtubular-mucocellular histology. | 0 |
| 38740643 | 2024 | Structural basis for the distinct roles of non-conserved Pro116 and conserved Tyr124 of BCH domain of yeast p50RhoGAP. | 0 |
| 38755445 | 2024 | Early gastric cancer with RhoGAP fusion is linked to frequent nodal metastasis and a part of microtubular-mucocellular histology. | 0 |
| 37254741 | 2023 | Cdc42GAP deficiency contributes to the Alzheimer's disease phenotype. | 2 |
| 37511111 | 2023 | The Role of ARHGAP1 in Rho GTPase Inactivation during Metastasizing of Breast Cancer Cell Line MCF-7 after Treatment with Doxorubicin. | 1 |
| 37254741 | 2023 | Cdc42GAP deficiency contributes to the Alzheimer's disease phenotype. | 2 |
| 37511111 | 2023 | The Role of ARHGAP1 in Rho GTPase Inactivation during Metastasizing of Breast Cancer Cell Line MCF-7 after Treatment with Doxorubicin. | 1 |
| 34402683 | 2022 | circRNA RPPH1 Facilitates the Aggravation of Breast Cancer Development by Regulating miR-542-3p/ARHGAP1 Pathway. | 8 |
| 34402683 | 2022 | circRNA RPPH1 Facilitates the Aggravation of Breast Cancer Development by Regulating miR-542-3p/ARHGAP1 Pathway. | 8 |
| 33279622 | 2021 | Angio-associated migratory cell protein (AAMP) interacts with cell division cycle 42 (CDC42) and enhances migration and invasion in human non-small cell lung cancer cells. | 7 |
| 34378285 | 2021 | Exosome miR-134-5p restrains breast cancer progression via regulating PI3K/AKT pathway by targeting ARHGAP1. | 12 |
| 33279622 | 2021 | Angio-associated migratory cell protein (AAMP) interacts with cell division cycle 42 (CDC42) and enhances migration and invasion in human non-small cell lung cancer cells. | 7 |
| 34378285 | 2021 | Exosome miR-134-5p restrains breast cancer progression via regulating PI3K/AKT pathway by targeting ARHGAP1. | 12 |
| 28748534 | 2017 | miR-130b directly targets ARHGAP1 to drive activation of a metastatic CDC42-PAK1-AP1 positive feedback loop in Ewing sarcoma. | 0 |
Citation
Dessen P
ARHGAP1 (Rho GTPase activating protein 1)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/694/arhgap1-(rho-gtpase-activating-protein-1)
