ARHGAP6 (Rho GTPase activating protein 6)

2003-11-01  

Identity

HGNC
ARHGAP6
LOCATION
Xp22.2
LOCUSID
395
ALIAS
RHOGAP6,RHOGAPX-1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 395
MIM: 300118
HGNC: 676
Ensembl: ENSG00000047648

Variants:

dbSNP: 395
ClinVar: 395
TCGA: ENSG00000047648
COSMIC: ARHGAP6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000047648ENST00000303025O43182
ENSG00000047648ENST00000337414O43182
ENSG00000047648ENST00000380717H7BYE6
ENSG00000047648ENST00000380718O43182
ENSG00000047648ENST00000380736O43182
ENSG00000047648ENST00000495242O43182
ENSG00000047648ENST00000657361B4DN07

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
232516832012Amelogenesis imperfecta in two families with defined AMELX deletions in ARHGAP6.9
199603752010Identification of Rho GTPase activating protein 6 isoform 1 variant as a new molecular marker in human colorectal tumors.3
184342372008Regulation of phospholipase C-delta1 by ARGHAP6, a GTPase-activating protein for RhoA: possible role for enhanced activity of phospholipase C in hypertension.2
308165462019ARHGAP6 regulates the proliferation, migration and invasion of lung cancer cells.1

Citation

Dessen P

ARHGAP6 (Rho GTPase activating protein 6)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/697/arhgap6-(rho-gtpase-activating-protein-6)