ARHGEF16 (Rho guanine nucleotide exchange factor 16)

2003-05-01 Affiliation

Identity

HGNC

ARHGEF16

LOCATION

1p36.32

LOCUSID

27237

ALIAS

GEF16,NBR

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 27237
MIM: 618871
HGNC: 15515
Ensembl: ENSG00000130762

Variants:

dbSNP: 27237
ClinVar: 27237
TCGA: ENSG00000130762
COSMIC: ARHGEF16

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000130762	ENST00000378371	Q5VV41
ENSG00000130762	ENST00000378373	Q5VV41
ENSG00000130762	ENST00000378378	Q5VV41
ENSG00000130762	ENST00000418137	B0QZD4
ENSG00000130762	ENST00000445297	B0QZD3

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Signal Transduction	REACTOME	R-HSA-162582
Signalling by NGF	REACTOME	R-HSA-166520
p75 NTR receptor-mediated signalling	REACTOME	R-HSA-193704
Cell death signalling via NRAGE, NRIF and NADE	REACTOME	R-HSA-204998
NRAGE signals death through JNK	REACTOME	R-HSA-193648
Signaling by Rho GTPases	REACTOME	R-HSA-194315
Rho GTPase cycle	REACTOME	R-HSA-194840
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (12/13) signalling events	REACTOME	R-HSA-416482

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
32811808	2020	FYN is required for ARHGEF16 to promote proliferation and migration in colon cancer cells.	12
32811808	2020	FYN is required for ARHGEF16 to promote proliferation and migration in colon cancer cells.	12
30305138	2018	GLI2 promotes cell proliferation and migration through transcriptional activation of ARHGEF16 in human glioma cells.	27
30305138	2018	GLI2 promotes cell proliferation and migration through transcriptional activation of ARHGEF16 in human glioma cells.	27
21139582	2011	The HPV16 E6 binding protein Tip-1 interacts with ARHGEF16, which activates Cdc42.	29
21139582	2011	The HPV16 E6 binding protein Tip-1 interacts with ARHGEF16, which activates Cdc42.	29
19911011	2010	Mutation of ARHGAP9 in patients with coronary spastic angina.	0
20679435	2010	Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism.	83
19911011	2010	Mutation of ARHGAP9 in patients with coronary spastic angina.	0
20679435	2010	Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism.	83
19707205	2009	Analogues of Y27632 increase gap junction communication and suppress the formation of transformed NIH3T3 colonies.	8
19707205	2009	Analogues of Y27632 increase gap junction communication and suppress the formation of transformed NIH3T3 colonies.	8

Citation

Dessen P

ARHGEF16 (Rho guanine nucleotide exchange factor 16)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/699/arhgef16-(rho-guanine-nucleotide-exchange-factor-16)