ARHGEF16 (Rho guanine nucleotide exchange factor 16)

2003-05-01  

Identity

HGNC
ARHGEF16
LOCATION
1p36.32
LOCUSID
27237
ALIAS
GEF16,NBR
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 27237
MIM: 618871
HGNC: 15515
Ensembl: ENSG00000130762

Variants:

dbSNP: 27237
ClinVar: 27237
TCGA: ENSG00000130762
COSMIC: ARHGEF16

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000130762ENST00000378371Q5VV41
ENSG00000130762ENST00000378373Q5VV41
ENSG00000130762ENST00000378378Q5VV41
ENSG00000130762ENST00000418137B0QZD4
ENSG00000130762ENST00000445297B0QZD3

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signalling by NGFREACTOMER-HSA-166520
p75 NTR receptor-mediated signallingREACTOMER-HSA-193704
Cell death signalling via NRAGE, NRIF and NADEREACTOMER-HSA-204998
NRAGE signals death through JNKREACTOMER-HSA-193648
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (12/13) signalling eventsREACTOMER-HSA-416482

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
206794352010Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism.53
211395822011The HPV16 E6 binding protein Tip-1 interacts with ARHGEF16, which activates Cdc42.23
197072052009Analogues of Y27632 increase gap junction communication and suppress the formation of transformed NIH3T3 colonies.8
199110112010Mutation of ARHGAP9 in patients with coronary spastic angina.5
303051382018GLI2 promotes cell proliferation and migration through transcriptional activation of ARHGEF16 in human glioma cells.5

Citation

Dessen P

ARHGEF16 (Rho guanine nucleotide exchange factor 16)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/699/arhgef16-(rho-guanine-nucleotide-exchange-factor-16)