ARHGEF4 (Rho guanine nucleotide exchange factor 4)

2003-02-01  

Identity

HGNC
LOCATION
2q21.1
LOCUSID
ALIAS
ASEF,ASEF1,GEF4,SMIM39,STM6
FUSION GENES

Other Information

Locus ID:

NCBI: 50649
MIM: 605216
HGNC: 684
Ensembl: ENSG00000136002

Variants:

dbSNP: 50649
ClinVar: 50649
TCGA: ENSG00000136002
COSMIC: ARHGEF4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136002ENST00000326016Q9NR80
ENSG00000136002ENST00000355771Q9NR80
ENSG00000136002ENST00000392953A0A0C4DFY6
ENSG00000136002ENST00000409303E9PEM0
ENSG00000136002ENST00000409359E7EV07
ENSG00000136002ENST00000428230A4QPB6
ENSG00000136002ENST00000438985H0Y451
ENSG00000136002ENST00000532720H0YCT6
ENSG00000136002ENST00000611048A0A087X0P1
ENSG00000136002ENST00000636987A0A1B0GW00

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Regulation of actin cytoskeletonKEGGko04810
Regulation of actin cytoskeletonKEGGhsa04810
Signal TransductionREACTOMER-HSA-162582
Signalling by NGFREACTOMER-HSA-166520
p75 NTR receptor-mediated signallingREACTOMER-HSA-193704
Cell death signalling via NRAGE, NRIF and NADEREACTOMER-HSA-204998
NRAGE signals death through JNKREACTOMER-HSA-193648
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (12/13) signalling eventsREACTOMER-HSA-416482

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
186535402008Phosphorylation and activation of the Rac1 and Cdc42 GEF Asef in A431 cells stimulated by EGF.29
255398522015Asef mediates HGF protective effects against LPS-induced lung injury and endothelial barrier dysfunction.15
217889862012Structural basis for the recognition of Asef by adenomatous polyposis coli.13
195252252009Adenomatous polyposis coli and Asef function downstream of hepatocyte growth factor and phosphatidylinositol 3-kinase.11
269299852016Quantitative genome-wide methylation analysis of high-grade non-muscle invasive bladder cancer.11
225439722012Small rare recurrent deletions and reciprocal duplications in 2q21.1, including brain-specific ARHGEF4 and GPR148.7
239419802013Association of Asef and Cdc42 expression to tubular injury in diseased human kidney.3
284289592017Copy Number Variations in Candidate Genes and Intergenic Regions Affect Body Mass Index and Abdominal Obesity in Mexican Children.3
302265822018ARHGEF4 predicts poor prognosis and promotes cell invasion by influencing ERK1/2 and GSK-3α/β signaling in pancreatic cancer.3
251018562014Hepatocyte growth factor triggers distinct mechanisms of Asef and Tiam1 activation to induce endothelial barrier enhancement.2

Citation

Dessen P

ARHGEF4 (Rho guanine nucleotide exchange factor 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/700/arhgef4-(rho-guanine-nucleotide-exchange-factor-4)