MPI (mannose phosphate isomerase)

2014-11-01  

Identity

HGNC
MPI
LOCATION
15q24.1
LOCUSID
4351
ALIAS
CDG1B,PMI,PMI1

Other Information

Locus ID:

NCBI: 4351
MIM: 154550
HGNC: 7216
Ensembl: ENSG00000178802

Variants:

dbSNP: 4351
ClinVar: 4351
TCGA: ENSG00000178802
COSMIC: MPI

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000178802ENST00000323744P34949
ENSG00000178802ENST00000352410P34949
ENSG00000178802ENST00000535694F5GX71
ENSG00000178802ENST00000561470H3BM77
ENSG00000178802ENST00000562606H3BT48
ENSG00000178802ENST00000562800H3BUG1
ENSG00000178802ENST00000563422H3BUZ9
ENSG00000178802ENST00000563786H3BPB8
ENSG00000178802ENST00000564003B4DYB8
ENSG00000178802ENST00000564633H3BPM5
ENSG00000178802ENST00000565576H3BMZ9
ENSG00000178802ENST00000566377H3BPP3
ENSG00000178802ENST00000567132H3BQX0
ENSG00000178802ENST00000567177H3BT46
ENSG00000178802ENST00000567570H3BPU7
ENSG00000178802ENST00000568828H3BNY8
ENSG00000178802ENST00000568907H3BU66
ENSG00000178802ENST00000569233H3BN01
ENSG00000178802ENST00000569931H3BP57

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Fructose and mannose metabolismKEGGko00051
Amino sugar and nucleotide sugar metabolismKEGGko00520
Fructose and mannose metabolismKEGGhsa00051
Amino sugar and nucleotide sugar metabolismKEGGhsa00520
Metabolic pathwaysKEGGhsa01100
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent proteinREACTOMER-HSA-446193
Synthesis of substrates in N-glycan biosythesisREACTOMER-HSA-446219
Synthesis of GDP-mannoseREACTOMER-HSA-446205

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
349585132022Selective Immobilization of His-Tagged Phosphomannose Isomerase on Ni Chelated Nanoparticles with Good Reusability and Activity.1
349585132022Selective Immobilization of His-Tagged Phosphomannose Isomerase on Ni Chelated Nanoparticles with Good Reusability and Activity.1
343138792021MPI-based bioinformatic analysis and co-inhibitory therapy with mannose for oral squamous cell carcinoma.1
343138792021MPI-based bioinformatic analysis and co-inhibitory therapy with mannose for oral squamous cell carcinoma.1
310167442019Mannose Phosphate Isomerase and Mannose Regulate Hepatic Stellate Cell Activation and Fibrosis in Zebrafish and Humans.12
310167442019Mannose Phosphate Isomerase and Mannose Regulate Hepatic Stellate Cell Activation and Fibrosis in Zebrafish and Humans.12
286441272017MPI depletion enhances O-GlcNAcylation of p53 and suppresses the Warburg effect.19
286441272017MPI depletion enhances O-GlcNAcylation of p53 and suppresses the Warburg effect.19
219492372011Phosphomannose isomerase inhibitors improve N-glycosylation in selected phosphomannomutase-deficient fibroblasts.27
219492372011Phosphomannose isomerase inhibitors improve N-glycosylation in selected phosphomannomutase-deficient fibroblasts.27
206286242010Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".30
206286242010Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".30
164881692006Computational study of human phosphomannose isomerase: Insights from homology modeling and molecular dynamics simulation of enzyme bound substrate.2
164881692006Computational study of human phosphomannose isomerase: Insights from homology modeling and molecular dynamics simulation of enzyme bound substrate.2

Citation

Dessen P

MPI (mannose phosphate isomerase)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/70392/mpi-(mannose-phosphate-isomerase)