MPST (mercaptopyruvate sulfurtransferase)

2014-11-01  

Identity

HGNC
MPST
LOCATION
22q12.3
LOCUSID
4357
ALIAS
MST,TST2,TUM1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4357
MIM: 602496
HGNC: 7223
Ensembl: ENSG00000128309

Variants:

dbSNP: 4357
ClinVar: 4357
TCGA: ENSG00000128309
COSMIC: MPST

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000128309ENST00000341116P25325
ENSG00000128309ENST00000341116A0A140VJX3
ENSG00000128309ENST00000397225P25325
ENSG00000128309ENST00000397225A0A140VJX3
ENSG00000128309ENST00000401419P25325
ENSG00000128309ENST00000401419A0A140VJX3
ENSG00000128309ENST00000404393B1AH49
ENSG00000128309ENST00000404802P25325
ENSG00000128309ENST00000404802A0A140VJX3
ENSG00000128309ENST00000429360P25325
ENSG00000128309ENST00000628507B1AH49

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Sulfur metabolismKEGGko00920
Sulfur metabolismKEGGhsa00920
Cysteine and methionine metabolismKEGGko00270
Cysteine and methionine metabolismKEGGhsa00270
Metabolic pathwaysKEGGhsa01100
Sulfur relay systemKEGGko04122
Sulfur relay systemKEGGhsa04122

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
386310982024Role of the 3-mercaptopyruvate sulfurtransferase in colon/colorectal cancers.0
386310982024Role of the 3-mercaptopyruvate sulfurtransferase in colon/colorectal cancers.0
3673261920233-Mercaptopyruvate sulfur transferase is a protein persulfidase.12
3673261920233-Mercaptopyruvate sulfur transferase is a protein persulfidase.12
3524374620223-Mercaptopyruvate sulfurtransferase represses tumour progression and predicts prognosis in hepatocellular carcinoma.7
361264192022MPST deficiency promotes intestinal epithelial cell apoptosis and aggravates inflammatory bowel disease via AKT.12
3524374620223-Mercaptopyruvate sulfurtransferase represses tumour progression and predicts prognosis in hepatocellular carcinoma.7
361264192022MPST deficiency promotes intestinal epithelial cell apoptosis and aggravates inflammatory bowel disease via AKT.12
3064409020203-Mercaptopyruvate sulfurtransferase supports endothelial cell angiogenesis and bioenergetics.25
321796472020Thioredoxin regulates human mercaptopyruvate sulfurtransferase at physiologically-relevant concentrations.21
3064409020203-Mercaptopyruvate sulfurtransferase supports endothelial cell angiogenesis and bioenergetics.25
321796472020Thioredoxin regulates human mercaptopyruvate sulfurtransferase at physiologically-relevant concentrations.21
3163448220193-Mercaptopyruvate sulfurtransferase disruption in dermal fibroblasts facilitates adipogenic trans-differentiation.3
3163448220193-Mercaptopyruvate sulfurtransferase disruption in dermal fibroblasts facilitates adipogenic trans-differentiation.3
265190302016MPST but not CSE is the primary regulator of hydrogen sulfide production and function in the coronary artery.21

Citation

Dessen P

MPST (mercaptopyruvate sulfurtransferase)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/70397/mpst-(mercaptopyruvate-sulfurtransferase)