MRAP2 (melanocortin 2 receptor accessory protein 2)

2014-11-01  

Identity

HGNC
MRAP2
LOCATION
6q14.2
LOCUSID
112609
ALIAS
C6orf117,bA51G5.2

Other Information

Locus ID:

NCBI: 112609
MIM: 615410
HGNC: 21232
Ensembl: ENSG00000135324

Variants:

dbSNP: 112609
ClinVar: 112609
TCGA: ENSG00000135324
COSMIC: MRAP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135324ENST00000257776Q96G30

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
325781252021Study of LEP, MRAP2 and POMC genes as potential causes of severe obesity in Brazilian patients.6
325781252021Study of LEP, MRAP2 and POMC genes as potential causes of severe obesity in Brazilian patients.6
319114342020The GPCR accessory protein MRAP2 regulates both biased signaling and constitutive activity of the ghrelin receptor GHSR1a.26
329435512020Membrane orientation and oligomerization of the melanocortin receptor accessory protein 2.8
319114342020The GPCR accessory protein MRAP2 regulates both biased signaling and constitutive activity of the ghrelin receptor GHSR1a.26
329435512020Membrane orientation and oligomerization of the melanocortin receptor accessory protein 2.8
309518542019MRAP2 regulates endometrial receptivity and function.3
317001712019Loss-of-function mutations in MRAP2 are pathogenic in hyperphagic obesity with hyperglycemia and hypertension.30
309518542019MRAP2 regulates endometrial receptivity and function.3
317001712019Loss-of-function mutations in MRAP2 are pathogenic in hyperphagic obesity with hyperglycemia and hypertension.30
284999892017Melanocortin Receptor Accessory Proteins (MRAPs): Functions in the melanocortin system and beyond.25
289390582017Regions of MRAP2 required for the inhibition of orexin and prokineticin receptor signaling.33
284999892017Melanocortin Receptor Accessory Proteins (MRAPs): Functions in the melanocortin system and beyond.25
289390582017Regions of MRAP2 required for the inhibition of orexin and prokineticin receptor signaling.33
267959562016Copy number variation (CNV) analysis and mutation analysis of the 6q14.1-6q16.3 genes SIM1 and MRAP2 in Prader Willi like patients.11

Citation

Dessen P

MRAP2 (melanocortin 2 receptor accessory protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/70405/mrap2-(melanocortin-2-receptor-accessory-protein-2)