MSMO1 (methylsterol monooxygenase 1)

2014-11-01  

Identity

HGNC
LOCATION
4q32.3
LOCUSID
ALIAS
DESP4,ERG25,MCCPD,SC4MOL
FUSION GENES

Other Information

Locus ID:

NCBI: 6307
MIM: 607545
HGNC: 10545
Ensembl: ENSG00000052802

Variants:

dbSNP: 6307
ClinVar: 6307
TCGA: ENSG00000052802
COSMIC: MSMO1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000052802ENST00000261507Q15800
ENSG00000052802ENST00000393766Q15800
ENSG00000052802ENST00000504317D6R952
ENSG00000052802ENST00000505270D6REA2
ENSG00000052802ENST00000507013D6RDP9

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Steroid biosynthesisKEGGko00100
Steroid biosynthesisKEGGhsa00100
Metabolic pathwaysKEGGhsa01100
Cholesterol biosynthesis, squalene 2,3-epoxide => cholesterolKEGGhsa_M00101
Cholesterol biosynthesis, squalene 2,3-epoxide => cholesterolKEGGM00101
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Cholesterol biosynthesisREACTOMER-HSA-191273

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
331614062020New Homozygous Missense MSMO1 Mutation in Two Siblings with SC4MOL Deficiency Presenting with Psoriasiform Dermatitis.4
331614062020New Homozygous Missense MSMO1 Mutation in Two Siblings with SC4MOL Deficiency Presenting with Psoriasiform Dermatitis.4
241447312014The role of sterol-C4-methyl oxidase in epidermal biology.15
241447312014The role of sterol-C4-methyl oxidase in epidermal biology.15
227917502012Genome-wide association study identifies novel loci association with fasting insulin and insulin resistance in African Americans.41
227917502012Genome-wide association study identifies novel loci association with fasting insulin and insulin resistance in African Americans.41
212855102011Mutations in the human SC4MOL gene encoding a methyl sterol oxidase cause psoriasiform dermatitis, microcephaly, and developmental delay.52
212855102011Mutations in the human SC4MOL gene encoding a methyl sterol oxidase cause psoriasiform dermatitis, microcephaly, and developmental delay.52
186604892008Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.29
186604892008Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.29

Citation

Dessen P

MSMO1 (methylsterol monooxygenase 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/70520/msmo1-(methylsterol-monooxygenase-1)