MTPN (myotrophin)

2014-11-01

Identity

HGNC

MTPN

LOCATION

7q33

LOCUSID

136319

ALIAS

GCDP,V-1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 136319
MIM: 606484
HGNC: 15667
Ensembl: ENSG00000105887

Variants:

dbSNP: 136319
ClinVar: 136319
TCGA: ENSG00000105887
COSMIC: MTPN

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000105887	ENST00000393085	P58546
ENSG00000105887	ENST00000393085	Q69YG1
ENSG00000105887	ENST00000435723	C9JL85

Expression (GTEx)

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
11971907	2002	Myotrophin/V-1, a protein up-regulated in the failing human heart and in postnatal cerebellum, converts NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers.	17
16982933	2006	An unconventional antigen translated by a novel internal ribosome entry site elicits antitumor humoral immune reactions.	18
16982933	2006	An unconventional antigen translated by a novel internal ribosome entry site elicits antitumor humoral immune reactions.	18
26274321	2015	The Human Myotrophin Variant Attenuates MicroRNA-Let-7 Binding Ability but Not Risk of Left Ventricular Hypertrophy in Human Essential Hypertension.	2
26274321	2015	The Human Myotrophin Variant Attenuates MicroRNA-Let-7 Binding Ability but Not Risk of Left Ventricular Hypertrophy in Human Essential Hypertension.	2
28300567	2017	9-cis Retinoic acid modulates myotrophin expression and its miR in physiological and pathophysiological cell models.	10
28300567	2017	9-cis Retinoic acid modulates myotrophin expression and its miR in physiological and pathophysiological cell models.	10
29847807	2018	Allosteric Coupling of CARMIL and V-1 Binding to Capping Protein Revealed by Hydrogen-Deuterium Exchange.	14
29847807	2018	Allosteric Coupling of CARMIL and V-1 Binding to Capping Protein Revealed by Hydrogen-Deuterium Exchange.	14
32483895	2020	Lysyl oxidase suppresses the inflammatory response in anterior cruciate ligament fibroblasts and promotes tissue regeneration by targeting myotrophin via the nuclear factor-kappa B pathway.	6

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Citation

Dessen P

MTPN (myotrophin)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/70564