Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 4580
MIM: 600605
HGNC: 7504
Ensembl: ENSG00000173171
Variants:
dbSNP: 4580
ClinVar: 4580
TCGA: ENSG00000173171
COSMIC: MTX1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000173171 | ENST00000316721 | Q13505 |
| ENSG00000173171 | ENST00000368376 | Q13505 |
| ENSG00000173171 | ENST00000424959 | H0Y6Y5 |
| ENSG00000173171 | ENST00000609421 | Q13505 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Metabolism of proteins | REACTOME | R-HSA-392499 |
| Mitochondrial protein import | REACTOME | R-HSA-1268020 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 34421355 | 2021 | Genome-scale CRISPRa screening identifies MTX1 as a contributor for sorafenib resistance in hepatocellular carcinoma by augmenting autophagy. | 8 |
| 34421355 | 2021 | Genome-scale CRISPRa screening identifies MTX1 as a contributor for sorafenib resistance in hepatocellular carcinoma by augmenting autophagy. | 8 |
| 27845183 | 2017 | The phosphorylation of Metaxin 1 controls Bak activation during TNFα induced cell death. | 10 |
| 27845183 | 2017 | The phosphorylation of Metaxin 1 controls Bak activation during TNFα induced cell death. | 10 |
| 21837367 | 2011 | Homozygosity for the MTX1 c.184T>A (p.S63T) alteration modifies the age of onset in GBA-associated Parkinson's disease. | 9 |
| 21837367 | 2011 | Homozygosity for the MTX1 c.184T>A (p.S63T) alteration modifies the age of onset in GBA-associated Parkinson's disease. | 9 |
| 20877624 | 2010 | Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. | 20 |
| 20877624 | 2010 | Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. | 20 |
| 17510655 | 2007 | Conserved roles of Sam50 and metaxins in VDAC biogenesis. | 49 |
| 17624330 | 2007 | The mitochondrial inner membrane protein mitofilin exists as a complex with SAM50, metaxins 1 and 2, coiled-coil-helix coiled-coil-helix domain-containing protein 3 and 6 and DnaJC11. | 87 |
| 17510655 | 2007 | Conserved roles of Sam50 and metaxins in VDAC biogenesis. | 49 |
| 17624330 | 2007 | The mitochondrial inner membrane protein mitofilin exists as a complex with SAM50, metaxins 1 and 2, coiled-coil-helix coiled-coil-helix domain-containing protein 3 and 6 and DnaJC11. | 87 |
| 15024629 | 2004 | A novel alteration in metaxin 1, F202L, is associated with N370S in Gaucher disease. | 2 |
| 15024629 | 2004 | A novel alteration in metaxin 1, F202L, is associated with N370S in Gaucher disease. | 2 |
Citation
Dessen P
MTX1 (metaxin 1)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/70578/mtx1-(metaxin-1)
