MYO9A (myosin IXA)

2014-11-01  

Identity

HGNC
MYO9A
LOCATION
15q23
LOCUSID
4649
ALIAS
CMS24
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4649
MIM: 604875
HGNC: 7608
Ensembl: ENSG00000066933

Variants:

dbSNP: 4649
ClinVar: 4649
TCGA: ENSG00000066933
COSMIC: MYO9A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000066933ENST00000356056B2RTY4
ENSG00000066933ENST00000424560B2RTY4
ENSG00000066933ENST00000444904B2RTY4
ENSG00000066933ENST00000561618H3BV44
ENSG00000066933ENST00000564571H3BRD5
ENSG00000066933ENST00000564931H3BSU8
ENSG00000066933ENST00000566885H3BMM1
ENSG00000066933ENST00000568042H3BU05
ENSG00000066933ENST00000568438H3BTL9
ENSG00000066933ENST00000568481H3BP49
ENSG00000066933ENST00000569314H3BMS3

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
334121622021Rho-GTPase Activating Protein myosin MYO9A identified as a novel candidate gene for monogenic focal segmental glomerulosclerosis.10
334121622021Rho-GTPase Activating Protein myosin MYO9A identified as a novel candidate gene for monogenic focal segmental glomerulosclerosis.10
324518672020Class IX Myosins: Motorized RhoGAP Signaling Molecules.4
324518672020Class IX Myosins: Motorized RhoGAP Signaling Molecules.4
272597562016Identification of mutations in the MYO9A gene in patients with congenital myasthenic syndrome.26
279566082016Self-organization of actin networks by a monomeric myosin.10
272597562016Identification of mutations in the MYO9A gene in patients with congenital myasthenic syndrome.26
279566082016Self-organization of actin networks by a monomeric myosin.10
238703132013Vaccinia virus F11 promotes viral spread by acting as a PDZ-containing scaffolding protein to bind myosin-9A and inhibit RhoA signaling.0
238703132013Vaccinia virus F11 promotes viral spread by acting as a PDZ-containing scaffolding protein to bind myosin-9A and inhibit RhoA signaling.0
223057562012Myosin-IXA regulates collective epithelial cell migration by targeting RhoGAP activity to cell-cell junctions.39
223057562012Myosin-IXA regulates collective epithelial cell migration by targeting RhoGAP activity to cell-cell junctions.39

Citation

Dessen P

MYO9A (myosin IXA)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/70635/myo9a-(myosin-ixa)