MYRIP (myosin VIIA and Rab interacting protein)

2014-11-01  

Identity

HGNC
MYRIP
LOCATION
3p22.1
LOCUSID
25924
ALIAS
SLAC2-C,SLAC2C
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 25924
MIM: 611790
HGNC: 19156
Ensembl: ENSG00000170011

Variants:

dbSNP: 25924
ClinVar: 25924
TCGA: ENSG00000170011
COSMIC: MYRIP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170011ENST00000302541Q8NFW9
ENSG00000170011ENST00000396217Q8NFW9
ENSG00000170011ENST00000425621Q8NFW9
ENSG00000170011ENST00000444716Q8NFW9
ENSG00000170011ENST00000458292Q8NFW9
ENSG00000170011ENST00000458441F8WFC5
ENSG00000170011ENST00000539167Q8NFW9

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Peptide hormone metabolismREACTOMER-HSA-2980736
Insulin processingREACTOMER-HSA-264876

References

Pubmed IDYearTitleCitations
266752352016Interaction between MyRIP and the actin cytoskeleton regulates Weibel-Palade body trafficking and exocytosis.22
266752352016Interaction between MyRIP and the actin cytoskeleton regulates Weibel-Palade body trafficking and exocytosis.22
223964292012Myrip couples the capture of secretory granules by the actin-rich cell cortex and their attachment to the plasma membrane.17
223964292012Myrip couples the capture of secretory granules by the actin-rich cell cortex and their attachment to the plasma membrane.17
217404912011Myosin Va acts in concert with Rab27a and MyRIP to regulate acute von-Willebrand factor release from endothelial cells.41
217404912011Myosin Va acts in concert with Rab27a and MyRIP to regulate acute von-Willebrand factor release from endothelial cells.41
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
208618662010Genome-wide association identifies SKIV2L and MYRIP as protective factors for age-related macular degeneration.35
208618662010Genome-wide association identifies SKIV2L and MYRIP as protective factors for age-related macular degeneration.35
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
208618662010Genome-wide association identifies SKIV2L and MYRIP as protective factors for age-related macular degeneration.35
208618662010Genome-wide association identifies SKIV2L and MYRIP as protective factors for age-related macular degeneration.35
192702612009Rab27a and MyRIP regulate the amount and multimeric state of VWF released from endothelial cells.54
192702612009Rab27a and MyRIP regulate the amount and multimeric state of VWF released from endothelial cells.54
184781592008Intramanchette transport during primate spermiogenesis: expression of dynein, myosin Va, motor recruiter myosin Va, VIIa-Rab27a/b interacting protein, and Rab27b in the manchette during human and monkey spermiogenesis.27

Citation

Dessen P

MYRIP (myosin VIIA and Rab interacting protein)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/70641/chromosome-explorer/new-content/