NAA30 (N-alpha-acetyltransferase 30, NatC catalytic subunit)

2014-11-01  

Identity

HGNC
NAA30
LOCATION
14q22.3
LOCUSID
122830
ALIAS
C14orf35,MAK3,Mak3p,NAT12,NAT12P
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 122830
MIM: 617989
HGNC: 19844
Ensembl: ENSG00000139977

Variants:

dbSNP: 122830
ClinVar: 122830
TCGA: ENSG00000139977
COSMIC: NAA30

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000139977ENST00000298406J3KNC2
ENSG00000139977ENST00000554703G3V3I2
ENSG00000139977ENST00000555166B4DK34
ENSG00000139977ENST00000556492Q147X3

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Retrograde transport at the Trans-Golgi-NetworkREACTOMER-HSA-6811440

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
292477992018Identification of an alternatively spliced nuclear isoform of human N-terminal acetyltransferase Naa30.10
292477992018Identification of an alternatively spliced nuclear isoform of human N-terminal acetyltransferase Naa30.10
283564832017Depletion of the human N-terminal acetyltransferase hNaa30 disrupts Golgi integrity and ARFRP1 localization.6
283564832017Depletion of the human N-terminal acetyltransferase hNaa30 disrupts Golgi integrity and ARFRP1 localization.6
276943312016A Role for Human N-alpha Acetyltransferase 30 (Naa30) in Maintaining Mitochondrial Integrity.30
276943312016A Role for Human N-alpha Acetyltransferase 30 (Naa30) in Maintaining Mitochondrial Integrity.30
262926632015Knockdown of NAT12/NAA30 reduces tumorigenic features of glioblastoma-initiating cells.17
262926632015Knockdown of NAT12/NAA30 reduces tumorigenic features of glioblastoma-initiating cells.17
193985762009Knockdown of human N alpha-terminal acetyltransferase complex C leads to p53-dependent apoptosis and aberrant human Arl8b localization.64
193985762009Knockdown of human N alpha-terminal acetyltransferase complex C leads to p53-dependent apoptosis and aberrant human Arl8b localization.64

Citation

Dessen P

NAA30 (N-alpha-acetyltransferase 30, NatC catalytic subunit)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/70658/naa30-(n-alpha-acetyltransferase-30-natc-catalytic-subunit)