NAPEPLD (N-acyl phosphatidylethanolamine phospholipase D)

2014-11-01  

Identity

HGNC
LOCATION
7q22.1
LOCUSID
ALIAS
C7orf18,FMP30,NAPE-PLD
FUSION GENES

Other Information

Locus ID:

NCBI: 222236
MIM: 612334
HGNC: 21683
Ensembl: ENSG00000161048

Variants:

dbSNP: 222236
ClinVar: 222236
TCGA: ENSG00000161048
COSMIC: NAPEPLD

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000161048ENST00000341533Q6IQ20
ENSG00000161048ENST00000417955Q6IQ20
ENSG00000161048ENST00000418294C9JGB1
ENSG00000161048ENST00000420631H0Y4Y2
ENSG00000161048ENST00000422589Q6IQ20
ENSG00000161048ENST00000427257Q6IQ20
ENSG00000161048ENST00000465647Q6IQ20

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Retrograde endocannabinoid signalingKEGGhsa04723
Retrograde endocannabinoid signalingKEGGko04723
DiseaseREACTOMER-HSA-1643685
Diseases of signal transductionREACTOMER-HSA-5663202
Diseases associated with visual transductionREACTOMER-HSA-2474795
Retinoid cycle disease eventsREACTOMER-HSA-2453864
Biosynthesis of A2E, implicated in retinal degradationREACTOMER-HSA-2466712
Signal TransductionREACTOMER-HSA-162582
Visual phototransductionREACTOMER-HSA-2187338
The canonical retinoid cycle in rods (twilight vision)REACTOMER-HSA-2453902

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
303993232019NAPE-PLD controls OEA synthesis and fat absorption by regulating lipoprotein synthesis in an in vitro model of intestinal epithelial cells.7
303993232019NAPE-PLD controls OEA synthesis and fat absorption by regulating lipoprotein synthesis in an in vitro model of intestinal epithelial cells.7
296529952018[Association of polymorphisms of NAPE-PLD and FAAH genes with schizophrenia in Chinese Han population].1
296529952018[Association of polymorphisms of NAPE-PLD and FAAH genes with schizophrenia in Chinese Han population].1
256845742015Structure of human N-acylphosphatidylethanolamine-hydrolyzing phospholipase D: regulation of fatty acid ethanolamide biosynthesis by bile acids.39
256845742015Structure of human N-acylphosphatidylethanolamine-hydrolyzing phospholipase D: regulation of fatty acid ethanolamide biosynthesis by bile acids.39
231226992013Differential expression of endocannabinoid system in normal and preeclamptic placentas: effects on nitric oxide synthesis.19
240184232013Isolevuglandin-modified phosphatidylethanolamine is metabolized by NAPE-hydrolyzing phospholipase D.9
241261892013No association of endocannabinoid genes with bipolar disorder or lithium response in a Sardinian sample.3
231226992013Differential expression of endocannabinoid system in normal and preeclamptic placentas: effects on nitric oxide synthesis.19
240184232013Isolevuglandin-modified phosphatidylethanolamine is metabolized by NAPE-hydrolyzing phospholipase D.9
241261892013No association of endocannabinoid genes with bipolar disorder or lithium response in a Sardinian sample.3
228279152012Developmental trajectory of the endocannabinoid system in human dorsolateral prefrontal cortex.40
228279152012Developmental trajectory of the endocannabinoid system in human dorsolateral prefrontal cortex.40
208853902011A common haplotype in NAPEPLD is associated with severe obesity in a Norwegian population-based cohort (the HUNT study).10

Citation

Dessen P

NAPEPLD (N-acyl phosphatidylethanolamine phospholipase D)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/70690/napepld-(n-acyl-phosphatidylethanolamine-phospholipase-d)