NCAN (neurocan)

2014-11-01  

Identity

HGNC
LOCATION
19p13.11
LOCUSID
ALIAS
CSPG3
FUSION GENES

Other Information

Locus ID:

NCBI: 1463
MIM: 600826
HGNC: 2465
Ensembl: ENSG00000130287

Variants:

dbSNP: 1463
ClinVar: 1463
TCGA: ENSG00000130287
COSMIC: NCAN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000130287ENST00000252575O14594
ENSG00000130287ENST00000252575A0A024R7M3
ENSG00000130287ENST00000588231K7EKF8

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
DiseaseREACTOMER-HSA-1643685
Diseases of glycosylationREACTOMER-HSA-3781865
Diseases associated with glycosaminoglycan metabolismREACTOMER-HSA-3560782
Defective B4GALT7 causes EDS, progeroid typeREACTOMER-HSA-3560783
Defective B3GAT3 causes JDSSDHDREACTOMER-HSA-3560801
Defective CHSY1 causes TPBSREACTOMER-HSA-3595177
Defective CHST3 causes SEDCJDREACTOMER-HSA-3595172
Defective CHST14 causes EDS, musculocontractural typeREACTOMER-HSA-3595174
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glycosaminoglycan metabolismREACTOMER-HSA-1630316
Heparan sulfate/heparin (HS-GAG) metabolismREACTOMER-HSA-1638091
A tetrasaccharide linker sequence is required for GAG synthesisREACTOMER-HSA-1971475
Chondroitin sulfate/dermatan sulfate metabolismREACTOMER-HSA-1793185
Chondroitin sulfate biosynthesisREACTOMER-HSA-2022870
Dermatan sulfate biosynthesisREACTOMER-HSA-2022923
CS/DS degradationREACTOMER-HSA-2024101
Extracellular matrix organizationREACTOMER-HSA-1474244
ECM proteoglycansREACTOMER-HSA-3000178
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
NCAM signaling for neurite out-growthREACTOMER-HSA-375165
NCAM1 interactionsREACTOMER-HSA-419037
L1CAM interactionsREACTOMER-HSA-373760
Defective B3GALT6 causes EDSP2 and SEMDJL1REACTOMER-HSA-4420332

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
325834662021Neurocan genome-wide psychiatric risk variant affects explicit memory performance and hippocampal function in healthy humans.10
325834662021Neurocan genome-wide psychiatric risk variant affects explicit memory performance and hippocampal function in healthy humans.10
267583782016Replication analysis of genetic association of the NCAN-CILP2 region with plasma lipid levels and non-alcoholic fatty liver disease in Asian and Pacific ethnic groups.3
278876082016Role of NCAN rs2228603 polymorphism in the incidence of nonalcoholic fatty liver disease: a case-control study.2
267583782016Replication analysis of genetic association of the NCAN-CILP2 region with plasma lipid levels and non-alcoholic fatty liver disease in Asian and Pacific ethnic groups.3
278876082016Role of NCAN rs2228603 polymorphism in the incidence of nonalcoholic fatty liver disease: a case-control study.2
252202932015A genome-wide supported psychiatric risk variant in NCAN influences brain function and cognitive performance in healthy subjects.15
258015002015NCAN Cross-Disorder Risk Variant Is Associated With Limbic Gray Matter Deficits in Healthy Subjects and Major Depression.10
252202932015A genome-wide supported psychiatric risk variant in NCAN influences brain function and cognitive performance in healthy subjects.15
258015002015NCAN Cross-Disorder Risk Variant Is Associated With Limbic Gray Matter Deficits in Healthy Subjects and Major Depression.10
237956792014Common variation in NCAN, a risk factor for bipolar disorder and schizophrenia, influences local cortical folding in schizophrenia.28
249462822014A common polymorphism in the NCAN gene is associated with hepatocellular carcinoma in alcoholic liver disease.11
249789032014TM6SF2 rs58542926 influences hepatic fibrosis progression in patients with non-alcoholic fatty liver disease.240
237956792014Common variation in NCAN, a risk factor for bipolar disorder and schizophrenia, influences local cortical folding in schizophrenia.28
249462822014A common polymorphism in the NCAN gene is associated with hepatocellular carcinoma in alcoholic liver disease.11

Citation

Dessen P

NCAN (neurocan)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/70727/ncan-(neurocan)