NDUFAF5 (NADH:ubiquinone oxidoreductase complex assembly factor 5)

2014-11-01  

Identity

HGNC
LOCATION
20p12.1
LOCUSID
ALIAS
C20orf7,MC1DN16,bA526K24.2,dJ842G6.1
FUSION GENES

Other Information

Locus ID:

NCBI: 79133
MIM: 612360
HGNC: 15899
Ensembl: ENSG00000101247

Variants:

dbSNP: 79133
ClinVar: 79133
TCGA: ENSG00000101247
COSMIC: NDUFAF5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101247ENST00000378081B3KR61
ENSG00000101247ENST00000378106Q5TEU4
ENSG00000101247ENST00000463598Q5TEU4

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
The citric acid (TCA) cycle and respiratory electron transportREACTOMER-HSA-1428517
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.REACTOMER-HSA-163200
Respiratory electron transportREACTOMER-HSA-611105
Complex I biogenesisREACTOMER-HSA-6799198

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
377186192024Unique prenatal manifestations of biallelic NDUFAF5 variants: expansion of phenotype.1
377186192024Unique prenatal manifestations of biallelic NDUFAF5 variants: expansion of phenotype.1
377528952023Phenotypic Heterogeneity in Patients with Mutations in the Mitochondrial Complex I Assembly Gene NDUFAF5.1
377528952023Phenotypic Heterogeneity in Patients with Mutations in the Mitochondrial Complex I Assembly Gene NDUFAF5.1
364217862022Mitochondrial Factor C20orf7 Facilitates the EMT-Mediated Cancer Cell Migration and the Proliferation of Colon Cancer In Vitro and In Vivo.0
364217862022Mitochondrial Factor C20orf7 Facilitates the EMT-Mediated Cancer Cell Migration and the Proliferation of Colon Cancer In Vitro and In Vivo.0
329189652021Nuclear DNA Mutation Causing a Phenotypic Leber Hereditary Optic Neuropathy Plus.4
329189652021Nuclear DNA Mutation Causing a Phenotypic Leber Hereditary Optic Neuropathy Plus.4
304734812019Novel mutations in the mitochondrial complex I assembly gene NDUFAF5 reveal heterogeneous phenotypes.17
304734812019Novel mutations in the mitochondrial complex I assembly gene NDUFAF5 reveal heterogeneous phenotypes.17
272266342016NDUFAF5 Hydroxylates NDUFS7 at an Early Stage in the Assembly of Human Complex I.20
272266342016NDUFAF5 Hydroxylates NDUFS7 at an Early Stage in the Assembly of Human Complex I.20
216077602012Combined OXPHOS complex I and IV defect, due to mutated complex I assembly factor C20ORF7.22
216077602012Combined OXPHOS complex I and IV defect, due to mutated complex I assembly factor C20ORF7.22
195420792010Defective complex I assembly due to C20orf7 mutations as a new cause of Leigh syndrome.29

Citation

Dessen P

NDUFAF5 (NADH:ubiquinone oxidoreductase complex assembly factor 5)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/70768/ndufaf5-(nadh-ubiquinone-oxidoreductase-complex-assembly-factor-5)