ARRB2 (arrestin beta 2)

2003-02-01  

Identity

HGNC
LOCATION
17p13.2
LOCUSID
ALIAS
ARB2,ARR2,BARR2
FUSION GENES

Other Information

Locus ID:

NCBI: 409
MIM: 107941
HGNC: 712
Ensembl: ENSG00000141480

Variants:

dbSNP: 409
ClinVar: 409
TCGA: ENSG00000141480
COSMIC: ARRB2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000141480ENST00000269260P32121
ENSG00000141480ENST00000346341P32121
ENSG00000141480ENST00000381488P32121
ENSG00000141480ENST00000412477P32121
ENSG00000141480ENST00000571206Q68DZ5
ENSG00000141480ENST00000571428K7EL17
ENSG00000141480ENST00000572457Q68DZ5
ENSG00000141480ENST00000572497I3L1M6
ENSG00000141480ENST00000574502I3L0V6
ENSG00000141480ENST00000574954Q68DZ5
ENSG00000141480ENST00000575877K7ENA6
ENSG00000141480ENST00000576235I3L412

Expression (GTEx)

0
100
200
300
400
500
600
700
800

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
Hedgehog signaling pathwayKEGGko04340
Olfactory transductionKEGGko04740
MAPK signaling pathwayKEGGhsa04010
Hedgehog signaling pathwayKEGGhsa04340
Olfactory transductionKEGGhsa04740
Chemokine signaling pathwayKEGGko04062
Chemokine signaling pathwayKEGGhsa04062
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Dopaminergic synapseKEGGko04728
Dopaminergic synapseKEGGhsa04728
Morphine addictionKEGGhsa05032
Morphine addictionKEGGko05032
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
DiseaseREACTOMER-HSA-1643685
Diseases of signal transductionREACTOMER-HSA-5663202
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
DAP12 interactionsREACTOMER-HSA-2172127
DAP12 signalingREACTOMER-HSA-2424491
RAF/MAP kinase cascadeREACTOMER-HSA-5673001
MAP2K and MAPK activationREACTOMER-HSA-5674135
Fc epsilon receptor (FCERI) signalingREACTOMER-HSA-2454202
FCERI mediated MAPK activationREACTOMER-HSA-2871796
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-2 signalingREACTOMER-HSA-451927
Interleukin receptor SHC signalingREACTOMER-HSA-912526
Interleukin-3, 5 and GM-CSF signalingREACTOMER-HSA-512988
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Thrombin signalling through proteinase activated receptors (PARs)REACTOMER-HSA-456926
Signal TransductionREACTOMER-HSA-162582
Signaling by EGFRREACTOMER-HSA-177929
GRB2 events in EGFR signalingREACTOMER-HSA-179812
SHC1 events in EGFR signalingREACTOMER-HSA-180336
Signaling by Insulin receptorREACTOMER-HSA-74752
Insulin receptor signalling cascadeREACTOMER-HSA-74751
IRS-mediated signallingREACTOMER-HSA-112399
SOS-mediated signallingREACTOMER-HSA-112412
Signalling by NGFREACTOMER-HSA-166520
NGF signalling via TRKA from the plasma membraneREACTOMER-HSA-187037
Signalling to ERKsREACTOMER-HSA-187687
Signalling to RASREACTOMER-HSA-167044
Signalling to p38 via RIT and RINREACTOMER-HSA-187706
Prolonged ERK activation eventsREACTOMER-HSA-169893
Frs2-mediated activationREACTOMER-HSA-170968
ARMS-mediated activationREACTOMER-HSA-170984
Signaling by PDGFREACTOMER-HSA-186797
Downstream signal transductionREACTOMER-HSA-186763
Signaling by VEGFREACTOMER-HSA-194138
VEGFA-VEGFR2 PathwayREACTOMER-HSA-4420097
VEGFR2 mediated cell proliferationREACTOMER-HSA-5218921
Signaling by SCF-KITREACTOMER-HSA-1433557
MAPK family signaling cascadesREACTOMER-HSA-5683057
MAPK1/MAPK3 signalingREACTOMER-HSA-5684996
Signaling by NOTCHREACTOMER-HSA-157118
Signaling by NOTCH1REACTOMER-HSA-1980143
Activated NOTCH1 Transmits Signal to the NucleusREACTOMER-HSA-2122948
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907
Signaling by WntREACTOMER-HSA-195721
Beta-catenin independent WNT signalingREACTOMER-HSA-3858494
PCP/CE pathwayREACTOMER-HSA-4086400
WNT5A-dependent internalization of FZD4REACTOMER-HSA-5099900
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)REACTOMER-HSA-2404192
IGF1R signaling cascadeREACTOMER-HSA-2428924
IRS-related events triggered by IGF1RREACTOMER-HSA-2428928
Signaling by LeptinREACTOMER-HSA-2586552
Signaling by HedgehogREACTOMER-HSA-5358351
Hedgehog 'on' stateREACTOMER-HSA-5632684
Activation of SMOREACTOMER-HSA-5635838
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
NCAM signaling for neurite out-growthREACTOMER-HSA-375165
Clathrin-mediated endocytosisREACTOMER-HSA-8856828
Cargo recognition for clathrin-mediated endocytosisREACTOMER-HSA-8856825
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880
RET signalingREACTOMER-HSA-8853659
Oncogenic MAPK signalingREACTOMER-HSA-6802957
Signaling by RAS mutantsREACTOMER-HSA-6802949
Signaling by high-kinase activity BRAF mutantsREACTOMER-HSA-6802948
Signaling by moderate kinase activity BRAF mutantsREACTOMER-HSA-6802946
Paradoxical activation of RAF signaling by kinase inactive BRAFREACTOMER-HSA-6802955
Signaling by BRAF and RAF fusionsREACTOMER-HSA-6802952

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA166151827adverse eventsDiseaseClinicalAnnotationassociatedPD30549211
PA264PDE4CGenePathwayassociated
PA30616MAPK1GenePathwayassociated
PA33128PDE4AGenePathwayassociated
PA33129PDE4BGenePathwayassociated
PA33130PDE4DGenePathwayassociated
PA33748PRKACAGenePathwayassociated
PA33749PRKACBGenePathwayassociated
PA33750PRKACGGenePathwayassociated
PA36111SRCGenePathwayassociated
PA39ADRB2GenePathwayassociated
PA445043Opioid-Related DisordersDiseaseClinicalAnnotationassociatedPD30549211
PA445208PainDiseaseVariantAnnotationnot associatedPD21398039
PA446876Substance-Related DisordersDiseaseClinicalAnnotationassociatedPD17233643
PA448685buprenorphineChemicalClinicalAnnotationassociatedPD30549211
PA449599fentanylChemicalClinicalAnnotationassociatedPD30549211
PA450403methamphetamineChemicalClinicalAnnotationassociatedPD17233643
PA451735tramadolChemicalClinicalAnnotationassociatedPD30549211
PA452618opioidsChemicalVariantAnnotationnot associatedPD21398039
PA62ATP1A1GenePathwayassociated23788015

References

Pubmed IDYearTitleCitations
129492612003Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2.216
168943952006The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes.153
129583642003Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4.138
123701872002Beta-arrestin2 is critically involved in CXCR4-mediated chemotaxis, and this is mediated by its enhancement of p38 MAPK activation.128
151258342004Identification of beta-arrestin2 as a G protein-coupled receptor-stimulated regulator of NF-kappaB pathways.109
156185192004Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2.98
198745742009Genetical genomic determinants of alcohol consumption in rats and humans.93
129583652003Beta-arrestin 2 mediates endocytosis of type III TGF-beta receptor and down-regulation of its signaling.92
125822072003Desensitization, internalization, and signaling functions of beta-arrestins demonstrated by RNA interference.90
186217172008Distinct conformational changes in beta-arrestin report biased agonism at seven-transmembrane receptors.88

Citation

Dessen P

ARRB2 (arrestin beta 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/708/arrb2-(arrestin-beta-2)