ARRB2 (arrestin beta 2)

2003-02-01 Affiliation

Identity

HGNC

ARRB2

LOCATION

17p13.2

LOCUSID

409

ALIAS

ARB2,ARR2,BARR2

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 409
MIM: 107941
HGNC: 712
Ensembl: ENSG00000141480

Variants:

dbSNP: 409
ClinVar: 409
TCGA: ENSG00000141480
COSMIC: ARRB2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000141480	ENST00000269260	P32121
ENSG00000141480	ENST00000346341	P32121
ENSG00000141480	ENST00000381488	P32121
ENSG00000141480	ENST00000412477	P32121
ENSG00000141480	ENST00000571206	Q68DZ5
ENSG00000141480	ENST00000571428	K7EL17
ENSG00000141480	ENST00000572457	Q68DZ5
ENSG00000141480	ENST00000572497	I3L1M6
ENSG00000141480	ENST00000574502	I3L0V6
ENSG00000141480	ENST00000574954	Q68DZ5
ENSG00000141480	ENST00000575877	K7ENA6
ENSG00000141480	ENST00000576235	I3L412

Expression (GTEx)

100

200

300

400

500

600

700

800

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
MAPK signaling pathway	KEGG	ko04010
Hedgehog signaling pathway	KEGG	ko04340
Olfactory transduction	KEGG	ko04740
MAPK signaling pathway	KEGG	hsa04010
Hedgehog signaling pathway	KEGG	hsa04340
Olfactory transduction	KEGG	hsa04740
Chemokine signaling pathway	KEGG	ko04062
Chemokine signaling pathway	KEGG	hsa04062
Endocytosis	KEGG	ko04144
Endocytosis	KEGG	hsa04144
Dopaminergic synapse	KEGG	ko04728
Dopaminergic synapse	KEGG	hsa04728
Morphine addiction	KEGG	hsa05032
Morphine addiction	KEGG	ko05032
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
Disease	REACTOME	R-HSA-1643685
Diseases of signal transduction	REACTOME	R-HSA-5663202
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
DAP12 interactions	REACTOME	R-HSA-2172127
DAP12 signaling	REACTOME	R-HSA-2424491
RAF/MAP kinase cascade	REACTOME	R-HSA-5673001
MAP2K and MAPK activation	REACTOME	R-HSA-5674135
Fc epsilon receptor (FCERI) signaling	REACTOME	R-HSA-2454202
FCERI mediated MAPK activation	REACTOME	R-HSA-2871796
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Signaling by Interleukins	REACTOME	R-HSA-449147
Interleukin-2 signaling	REACTOME	R-HSA-451927
Interleukin receptor SHC signaling	REACTOME	R-HSA-912526
Interleukin-3, 5 and GM-CSF signaling	REACTOME	R-HSA-512988
Hemostasis	REACTOME	R-HSA-109582
Platelet activation, signaling and aggregation	REACTOME	R-HSA-76002
Thrombin signalling through proteinase activated receptors (PARs)	REACTOME	R-HSA-456926
Signal Transduction	REACTOME	R-HSA-162582
Signaling by EGFR	REACTOME	R-HSA-177929
GRB2 events in EGFR signaling	REACTOME	R-HSA-179812
SHC1 events in EGFR signaling	REACTOME	R-HSA-180336
Signaling by Insulin receptor	REACTOME	R-HSA-74752
Insulin receptor signalling cascade	REACTOME	R-HSA-74751
IRS-mediated signalling	REACTOME	R-HSA-112399
SOS-mediated signalling	REACTOME	R-HSA-112412
Signalling by NGF	REACTOME	R-HSA-166520
NGF signalling via TRKA from the plasma membrane	REACTOME	R-HSA-187037
Signalling to ERKs	REACTOME	R-HSA-187687
Signalling to RAS	REACTOME	R-HSA-167044
Signalling to p38 via RIT and RIN	REACTOME	R-HSA-187706
Prolonged ERK activation events	REACTOME	R-HSA-169893
Frs2-mediated activation	REACTOME	R-HSA-170968
ARMS-mediated activation	REACTOME	R-HSA-170984
Signaling by PDGF	REACTOME	R-HSA-186797
Downstream signal transduction	REACTOME	R-HSA-186763
Signaling by VEGF	REACTOME	R-HSA-194138
VEGFA-VEGFR2 Pathway	REACTOME	R-HSA-4420097
VEGFR2 mediated cell proliferation	REACTOME	R-HSA-5218921
Signaling by SCF-KIT	REACTOME	R-HSA-1433557
MAPK family signaling cascades	REACTOME	R-HSA-5683057
MAPK1/MAPK3 signaling	REACTOME	R-HSA-5684996
Signaling by NOTCH	REACTOME	R-HSA-157118
Signaling by NOTCH1	REACTOME	R-HSA-1980143
Activated NOTCH1 Transmits Signal to the Nucleus	REACTOME	R-HSA-2122948
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (s) signalling events	REACTOME	R-HSA-418555
Gastrin-CREB signalling pathway via PKC and MAPK	REACTOME	R-HSA-881907
Signaling by Wnt	REACTOME	R-HSA-195721
Beta-catenin independent WNT signaling	REACTOME	R-HSA-3858494
PCP/CE pathway	REACTOME	R-HSA-4086400
WNT5A-dependent internalization of FZD4	REACTOME	R-HSA-5099900
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	REACTOME	R-HSA-2404192
IGF1R signaling cascade	REACTOME	R-HSA-2428924
IRS-related events triggered by IGF1R	REACTOME	R-HSA-2428928
Signaling by Leptin	REACTOME	R-HSA-2586552
Signaling by Hedgehog	REACTOME	R-HSA-5358351
Hedgehog 'on' state	REACTOME	R-HSA-5632684
Activation of SMO	REACTOME	R-HSA-5635838
Vesicle-mediated transport	REACTOME	R-HSA-5653656
Membrane Trafficking	REACTOME	R-HSA-199991
Developmental Biology	REACTOME	R-HSA-1266738
Axon guidance	REACTOME	R-HSA-422475
NCAM signaling for neurite out-growth	REACTOME	R-HSA-375165
Clathrin-mediated endocytosis	REACTOME	R-HSA-8856828
Cargo recognition for clathrin-mediated endocytosis	REACTOME	R-HSA-8856825
Deubiquitination	REACTOME	R-HSA-5688426
Ub-specific processing proteases	REACTOME	R-HSA-5689880
RET signaling	REACTOME	R-HSA-8853659
Oncogenic MAPK signaling	REACTOME	R-HSA-6802957
Signaling by RAS mutants	REACTOME	R-HSA-6802949
Signaling by high-kinase activity BRAF mutants	REACTOME	R-HSA-6802948
Signaling by moderate kinase activity BRAF mutants	REACTOME	R-HSA-6802946
Paradoxical activation of RAF signaling by kinase inactive BRAF	REACTOME	R-HSA-6802955
Signaling by BRAF and RAF fusions	REACTOME	R-HSA-6802952

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA166151827	adverse events	Disease	ClinicalAnnotation	associated	PD	30549211
PA264	PDE4C	Gene	Pathway	associated
PA30616	MAPK1	Gene	Pathway	associated
PA33128	PDE4A	Gene	Pathway	associated
PA33129	PDE4B	Gene	Pathway	associated
PA33130	PDE4D	Gene	Pathway	associated
PA33748	PRKACA	Gene	Pathway	associated
PA33749	PRKACB	Gene	Pathway	associated
PA33750	PRKACG	Gene	Pathway	associated
PA36111	SRC	Gene	Pathway	associated
PA39	ADRB2	Gene	Pathway	associated
PA445043	Opioid-Related Disorders	Disease	ClinicalAnnotation	associated	PD	30549211
PA445208	Pain	Disease	VariantAnnotation	not associated	PD	21398039
PA446876	Substance-Related Disorders	Disease	ClinicalAnnotation	associated	PD	17233643
PA448685	buprenorphine	Chemical	ClinicalAnnotation	associated	PD	30549211
PA449599	fentanyl	Chemical	ClinicalAnnotation	associated	PD	30549211
PA450403	methamphetamine	Chemical	ClinicalAnnotation	associated	PD	17233643
PA451735	tramadol	Chemical	ClinicalAnnotation	associated	PD	30549211
PA452618	opioids	Chemical	VariantAnnotation	not associated	PD	21398039
PA62	ATP1A1	Gene	Pathway	associated		23788015

References

Pubmed ID	Year	Title	Citations
38267365	2024	Arrestin beta-2 deficiency exacerbates periodontal inflammation by mediating activating transcription factor 6 activation and abnormal remodelling of the extracellular matrix.	1
38267365	2024	Arrestin beta-2 deficiency exacerbates periodontal inflammation by mediating activating transcription factor 6 activation and abnormal remodelling of the extracellular matrix.	1
36744494	2023	Dysregulated Smooth Muscle Cell BMPR2-ARRB2 Axis Causes Pulmonary Hypertension.	8
37100034	2023	A Common Variant of ARRB2 Promoter Region Associated with the Prognosis of Heart Failure.	0
36744494	2023	Dysregulated Smooth Muscle Cell BMPR2-ARRB2 Axis Causes Pulmonary Hypertension.	8
37100034	2023	A Common Variant of ARRB2 Promoter Region Associated with the Prognosis of Heart Failure.	0
35189719	2022	Association of polymorphisms in ARRB2 and clinical response to methadone for pain in advanced cancer.	1
35788718	2022	LncRNA GATA3-AS1 promoted invasion and migration in human endometrial carcinoma by regulating the miR-361/ARRB2 axis.	1
36284990	2022	The Comprehensive Analysis of Hub Gene ARRB2 in Prostate Cancer.	2
35189719	2022	Association of polymorphisms in ARRB2 and clinical response to methadone for pain in advanced cancer.	1
35788718	2022	LncRNA GATA3-AS1 promoted invasion and migration in human endometrial carcinoma by regulating the miR-361/ARRB2 axis.	1
36284990	2022	The Comprehensive Analysis of Hub Gene ARRB2 in Prostate Cancer.	2
33288675	2021	Direct evidence that the GPCR CysLTR2 mutant causative of uveal melanoma is constitutively active with highly biased signaling.	17
33367479	2021	ARRB2 promotes colorectal cancer growth through triggering WTAP.	9
33649538	2021	The RanBP2/RanGAP1-SUMO complex gates β-arrestin2 nuclear entry to regulate the Mdm2-p53 signaling axis.	8

Citation

Dessen P

ARRB2 (arrestin beta 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/708/arrb2-(arrestin-beta-2)

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