NLGN2 (neuroligin 2)

2014-11-01  

Identity

HGNC
LOCATION
17p13.1
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 57555
MIM: 606479
HGNC: 14290
Ensembl: ENSG00000169992

Variants:

dbSNP: 57555
ClinVar: 57555
TCGA: ENSG00000169992
COSMIC: NLGN2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000169992ENST00000302926Q8NFZ4
ENSG00000169992ENST00000570940I3L498
ENSG00000169992ENST00000575301Q8NFZ4

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Cell adhesion molecules (CAMs)KEGGhsa04514
Neuronal SystemREACTOMER-HSA-112316
Protein-protein interactions at synapsesREACTOMER-HSA-6794362
Interactions of neurexins and neuroligins at synapsesREACTOMER-HSA-6794361

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
364792162022Expression and structural analysis of human neuroligin 2 and neuroligin 3 implicated in autism spectrum disorders.2
364792162022Expression and structural analysis of human neuroligin 2 and neuroligin 3 implicated in autism spectrum disorders.2
331276422020Neuroligin-2 dependent conformational activation of collybistin reconstituted in supported hybrid membranes.4
334432302020Neuroligin-2 as a central organizer of inhibitory synapses in health and disease.16
331276422020Neuroligin-2 dependent conformational activation of collybistin reconstituted in supported hybrid membranes.4
334432302020Neuroligin-2 as a central organizer of inhibitory synapses in health and disease.16
293394862018Cell-type-specific role for nucleus accumbens neuroligin-2 in depression and stress susceptibility.34
293394862018Cell-type-specific role for nucleus accumbens neuroligin-2 in depression and stress susceptibility.34
278650482017Neuroligin 2 nonsense variant associated with anxiety, autism, intellectual disability, hyperphagia, and obesity.36
286411122017Molecular Mechanism of MDGA1: Regulation of Neuroligin 2:Neurexin Trans-synaptic Bridges.31
278650482017Neuroligin 2 nonsense variant associated with anxiety, autism, intellectual disability, hyperphagia, and obesity.36
286411122017Molecular Mechanism of MDGA1: Regulation of Neuroligin 2:Neurexin Trans-synaptic Bridges.31
278055702016Distinct roles for extracellular and intracellular domains in neuroligin function at inhibitory synapses.24
278055702016Distinct roles for extracellular and intracellular domains in neuroligin function at inhibitory synapses.24
248425552014The down-regulation of neuroligin-2 and the correlative clinical significance of serum GABA over-expression in Hirschsprung's disease.6

Citation

Dessen P

NLGN2 (neuroligin 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/70863/nlgn2-(neuroligin-2)