Identity
HGNC
LOCATION
19q13.43
LOCUSID
ALIAS
CLR19.5,CT58,NALP4,PAN2,PYPAF4,RNH2
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 147945
MIM: 609645
HGNC: 22943
Ensembl: ENSG00000160505
Variants:
dbSNP: 147945
ClinVar: 147945
TCGA: ENSG00000160505
COSMIC: NLRP4
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000160505 | ENST00000301295 | Q96MN2 |
| ENSG00000160505 | ENST00000587464 | K7ES09 |
| ENSG00000160505 | ENST00000587891 | Q96MN2 |
| ENSG00000160505 | ENST00000589437 | K7ESK5 |
Expression (GTEx)
Pathways
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 34927309 | 2022 | NLRP4 negatively regulates type I interferon response and influences the outcome in anti-programmed cell death protein (PD)-1/PD-ligand 1 therapy. | 9 |
| 35467709 | 2022 | The hyper-expression of NLRP4 characterizes the occurrence of macrophage activation syndrome assessing STING pathway in adult-onset Still's disease. | 1 |
| 34927309 | 2022 | NLRP4 negatively regulates type I interferon response and influences the outcome in anti-programmed cell death protein (PD)-1/PD-ligand 1 therapy. | 9 |
| 35467709 | 2022 | The hyper-expression of NLRP4 characterizes the occurrence of macrophage activation syndrome assessing STING pathway in adult-onset Still's disease. | 1 |
| 34257569 | 2021 | Somatic Mutation of NLRP Genes in Gastric and Colonic Cancers. | 3 |
| 34257569 | 2021 | Somatic Mutation of NLRP Genes in Gastric and Colonic Cancers. | 3 |
| 30526007 | 2019 | Association of Genetic Variants of NLRP4 with Exacerbation of Asthma: The Effect of Smoking. | 9 |
| 30526007 | 2019 | Association of Genetic Variants of NLRP4 with Exacerbation of Asthma: The Effect of Smoking. | 9 |
| 28486191 | 2017 | NLRP4 is an essential negative regulator of fructose-induced cardiac injury in vitro and in vivo. | 10 |
| 29099277 | 2017 | The intracellular microbial sensor NLRP4 directs Rho-actin signaling to facilitate Group A Streptococcus-containing autophagosome-like vacuole formation. | 10 |
| 28486191 | 2017 | NLRP4 is an essential negative regulator of fructose-induced cardiac injury in vitro and in vivo. | 10 |
| 29099277 | 2017 | The intracellular microbial sensor NLRP4 directs Rho-actin signaling to facilitate Group A Streptococcus-containing autophagosome-like vacuole formation. | 10 |
| 25403012 | 2015 | Intrinsic flexibility of NLRP pyrin domains is a key factor in their conformational dynamics, fold stability, and dimerization. | 12 |
| 25403012 | 2015 | Intrinsic flexibility of NLRP pyrin domains is a key factor in their conformational dynamics, fold stability, and dimerization. | 12 |
| 24871464 | 2014 | The CLRX.1/NOD24 (NLRP2P) pseudogene codes a functional negative regulator of NF-κB, pyrin-only protein 4. | 15 |
Citation
Dessen P
NLRP4 (NLR family pyrin domain containing 4)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/70876/nlrp4-(nlr-family-pyrin-domain-containing-4)
