NMRK1 (nicotinamide riboside kinase 1)

2014-11-01  

Identity

HGNC
NMRK1
LOCATION
9q21.13
LOCUSID
54981
ALIAS
C9orf95,NRK1,bA235O14.2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 54981
MIM: 608704
HGNC: 26057
Ensembl: ENSG00000106733

Variants:

dbSNP: 54981
ClinVar: 54981
TCGA: ENSG00000106733
COSMIC: NMRK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000106733ENST00000361092Q9NWW6
ENSG00000106733ENST00000376808Q9NWW6
ENSG00000106733ENST00000376811Q5W125
ENSG00000106733ENST00000494066B3KN26

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Nicotinate and nicotinamide metabolismKEGGko00760
Nicotinate and nicotinamide metabolismKEGGhsa00760
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of vitamins and cofactorsREACTOMER-HSA-196854
Metabolism of water-soluble vitamins and cofactorsREACTOMER-HSA-196849
Nicotinate metabolismREACTOMER-HSA-196807

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
277256752016NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells.168
277256752016NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells.168
176980032007Crystal structure of human nicotinamide riboside kinase.13
176980032007Crystal structure of human nicotinamide riboside kinase.13

Citation

Dessen P

NMRK1 (nicotinamide riboside kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/70888/nmrk1-(nicotinamide-riboside-kinase-1)