NOSIP (nitric oxide synthase interacting protein)

2014-11-01  

Identity

HGNC
NOSIP
LOCATION
19q13.33
LOCUSID
51070
ALIAS
CGI-25

Other Information

Locus ID:

NCBI: 51070
MIM: 616759
HGNC: 17946
Ensembl: ENSG00000142546

Variants:

dbSNP: 51070
ClinVar: 51070
TCGA: ENSG00000142546
COSMIC: NOSIP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000142546ENST00000339093A0A075B6F9
ENSG00000142546ENST00000594932M0R1T7
ENSG00000142546ENST00000596358Q9Y314
ENSG00000142546ENST00000598296M0R1K2
ENSG00000142546ENST00000598544M0QX85
ENSG00000142546ENST00000599537M0R3B2
ENSG00000142546ENST00000600019M0R1T7
ENSG00000142546ENST00000601015A0A075B797

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of nitric oxideREACTOMER-HSA-202131
eNOS activation and regulationREACTOMER-HSA-203765
NOSIP mediated eNOS traffickingREACTOMER-HSA-203754

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
366902762023Transportin 1 is a major nuclear import receptor of the nitric oxide synthase interacting protein.0
366902762023Transportin 1 is a major nuclear import receptor of the nitric oxide synthase interacting protein.0
337715752021nNOS induction and NOSIP interaction impact granulopoiesis and neutrophil differentiation by modulating nitric oxide generation.6
337715752021nNOS induction and NOSIP interaction impact granulopoiesis and neutrophil differentiation by modulating nitric oxide generation.6
281966632017NOS-interacting protein (NOSIP) is increased in the colon of patients with Hirschsprungs's disease.6
281966632017NOS-interacting protein (NOSIP) is increased in the colon of patients with Hirschsprungs's disease.6
161358132005Cell cycle-regulated inactivation of endothelial NO synthase through NOSIP-dependent targeting to the cytoskeleton.18
161358132005Cell cycle-regulated inactivation of endothelial NO synthase through NOSIP-dependent targeting to the cytoskeleton.18
111498952001NOSIP, a novel modulator of endothelial nitric oxide synthase activity.58
111498952001NOSIP, a novel modulator of endothelial nitric oxide synthase activity.58

Citation

Dessen P

NOSIP (nitric oxide synthase interacting protein)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/70909/nosip-(nitric-oxide-synthase-interacting-protein)