NPAS4 (neuronal PAS domain protein 4)

2014-11-01  

Identity

HGNC
LOCATION
11q13.2
LOCUSID
ALIAS
Le-PAS,NXF,PASD10,bHLHe79

Other Information

Locus ID:

NCBI: 266743
MIM: 608554
HGNC: 18983
Ensembl: ENSG00000174576

Variants:

dbSNP: 266743
ClinVar: 266743
TCGA: ENSG00000174576
COSMIC: NPAS4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000174576ENST00000311034Q8IUM7
ENSG00000174576ENST00000525148Q8IUM7
ENSG00000174576ENST00000639555Q8IUM7

Expression (GTEx)

0
5
10
15
20

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
380620592023Downregulated NPAS4 in multiple brain regions is associated with major depressive disorder.0
380620592023Downregulated NPAS4 in multiple brain regions is associated with major depressive disorder.0
363432532022Structures of NPAS4-ARNT and NPAS4-ARNT2 heterodimers reveal new dimerization modalities in the bHLH-PAS transcription factor family.0
363432532022Structures of NPAS4-ARNT and NPAS4-ARNT2 heterodimers reveal new dimerization modalities in the bHLH-PAS transcription factor family.0
337198212021Circular RNA circ_0003420 mediates inflammation in sepsis-induced liver damage by downregulating neuronal PAS domain protein 4.6
337582882021Molecular characterisation of rare loss-of-function NPAS3 and NPAS4 variants identified in individuals with neurodevelopmental disorders.3
337198212021Circular RNA circ_0003420 mediates inflammation in sepsis-induced liver damage by downregulating neuronal PAS domain protein 4.6
337582882021Molecular characterisation of rare loss-of-function NPAS3 and NPAS4 variants identified in individuals with neurodevelopmental disorders.3
280824512017The neuronal transcription factor NPAS4 is a strong inducer of sprouting angiogenesis and tip cell formation.6
280824512017The neuronal transcription factor NPAS4 is a strong inducer of sprouting angiogenesis and tip cell formation.6
266901242015The Role of the Neuroprotective Factor Npas4 in Cerebral Ischemia.23
266901242015The Role of the Neuroprotective Factor Npas4 in Cerebral Ischemia.23
244656932014Human variants in the neuronal basic helix-loop-helix/Per-Arnt-Sim (bHLH/PAS) transcription factor complex NPAS4/ARNT2 disrupt function.13
248875582014A reduction in Npas4 expression results in delayed neural differentiation of mouse embryonic stem cells.7
244656932014Human variants in the neuronal basic helix-loop-helix/Per-Arnt-Sim (bHLH/PAS) transcription factor complex NPAS4/ARNT2 disrupt function.13

Citation

Dessen P

NPAS4 (neuronal PAS domain protein 4)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/70914/npas4-(neuronal-pas-domain-protein-4)