NPFF (neuropeptide FF-amide peptide precursor)

2014-11-01  

Identity

HGNC
LOCATION
12q13.13
LOCUSID
ALIAS
FMRFAL

Other Information

Locus ID:

NCBI: 8620
MIM: 604643
HGNC: 7901
Ensembl: ENSG00000139574

Variants:

dbSNP: 8620
ClinVar: 8620
TCGA: ENSG00000139574
COSMIC: NPFF

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000139574ENST00000267017O15130

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
Orexin and neuropeptides FF and QRFP bind to their respective receptorsREACTOMER-HSA-389397
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

References

Pubmed IDYearTitleCitations
389652512024Renal autocrine neuropeptide FF (NPFF) signaling regulates blood pressure.0
389652512024Renal autocrine neuropeptide FF (NPFF) signaling regulates blood pressure.0
345347162021The distribution of Neuropeptide FF and Neuropeptide VF in central and peripheral tissues and their role in energy homeostasis control.3
345347162021The distribution of Neuropeptide FF and Neuropeptide VF in central and peripheral tissues and their role in energy homeostasis control.3
266605312016Gene-based pleiotropy across migraine with aura and migraine without aura patient groups.31
266605312016Gene-based pleiotropy across migraine with aura and migraine without aura patient groups.31
211209302011Vasopressin (VP) and neuropeptide FF (NPFF) systems in the normal and hypertensive human brainstem.9
211209302011Vasopressin (VP) and neuropeptide FF (NPFF) systems in the normal and hypertensive human brainstem.9
178548902008Modulatory role of neuropeptide FF system in nociception and opiate analgesia.33
178548902008Modulatory role of neuropeptide FF system in nociception and opiate analgesia.33
172244502007Physical association between neuropeptide FF and micro-opioid receptors as a possible molecular basis for anti-opioid activity.11
172244502007Physical association between neuropeptide FF and micro-opioid receptors as a possible molecular basis for anti-opioid activity.11
163362162006Regulation of endogenous human NPFF2 receptor by neuropeptide FF in SK-N-MC neuroblastoma cell line.3
163362162006Regulation of endogenous human NPFF2 receptor by neuropeptide FF in SK-N-MC neuroblastoma cell line.3

Citation

Dessen P

NPFF (neuropeptide FF-amide peptide precursor)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/70920/npff-(neuropeptide-ff-amide-peptide-precursor)