NPFFR2 (neuropeptide FF receptor 2)

2014-11-01  

Identity

HGNC
LOCATION
4q13.3
LOCUSID
ALIAS
GPR74,HLWAR77,NPFF2,NPGPR
FUSION GENES

Other Information

Locus ID:

NCBI: 10886
MIM: 607449
HGNC: 4525
Ensembl: ENSG00000056291

Variants:

dbSNP: 10886
ClinVar: 10886
TCGA: ENSG00000056291
COSMIC: NPFFR2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000056291ENST00000308744Q9Y5X5
ENSG00000056291ENST00000344413Q9Y5X5
ENSG00000056291ENST00000358749Q9Y5X5
ENSG00000056291ENST00000358749A0PJM9
ENSG00000056291ENST00000395999Q9Y5X5

Expression (GTEx)

0
1

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
Orexin and neuropeptides FF and QRFP bind to their respective receptorsREACTOMER-HSA-389397
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

References

Pubmed IDYearTitleCitations
365354642023NPFFR2 gene compound heterozygous variants associated with preeclampsia identified by whole-exome sequencing.0
365354642023NPFFR2 gene compound heterozygous variants associated with preeclampsia identified by whole-exome sequencing.0
330582332020Genome-wide association analysis of psoriasis patients treated with anti-TNF drugs.10
330582332020Genome-wide association analysis of psoriasis patients treated with anti-TNF drugs.10
262118942015Effects of systematic N-terminus deletions and benzoylations of endogenous RF-amide peptides on NPFF1R, NPFF2R, GPR10, GPR54 and GPR103.8
262118942015Effects of systematic N-terminus deletions and benzoylations of endogenous RF-amide peptides on NPFF1R, NPFF2R, GPR10, GPR54 and GPR103.8
253263822014Identification and functional characterization of the phosphorylation sites of the neuropeptide FF2 receptor.7
253263822014Identification and functional characterization of the phosphorylation sites of the neuropeptide FF2 receptor.7
223750002012GRK2 protein-mediated transphosphorylation contributes to loss of function of μ-opioid receptors induced by neuropeptide FF (NPFF2) receptors.17
223750002012GRK2 protein-mediated transphosphorylation contributes to loss of function of μ-opioid receptors induced by neuropeptide FF (NPFF2) receptors.17
218181522011Polymorphisms in the NPY2R gene show significant associations with BMI that are additive to FTO, MC4R, and NPFFR2 gene effects.17
218181522011Polymorphisms in the NPY2R gene show significant associations with BMI that are additive to FTO, MC4R, and NPFFR2 gene effects.17
199447302010Pharmacological characterization of the mouse NPFF2 receptor.7
206006362010Human kisspeptins activate neuropeptide FF2 receptor.20
199447302010Pharmacological characterization of the mouse NPFF2 receptor.7

Citation

Dessen P

NPFFR2 (neuropeptide FF receptor 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/70922/