NPM2 (nucleophosmin/nucleoplasmin 2)

2014-11-01  

Identity

HGNC
LOCATION
8p21.3
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 10361
MIM: 608073
HGNC: 7930
Ensembl: ENSG00000158806

Variants:

dbSNP: 10361
ClinVar: 10361
TCGA: ENSG00000158806
COSMIC: NPM2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000158806ENST00000289820Q86SE8
ENSG00000158806ENST00000381530Q86SE8
ENSG00000158806ENST00000397940Q86SE8
ENSG00000158806ENST00000518119Q86SE8
ENSG00000158806ENST00000520125E5RGN1
ENSG00000158806ENST00000521157Q86SE8
ENSG00000158806ENST00000522813E5RFQ8
ENSG00000158806ENST00000615914Q86SE8
ENSG00000158806ENST00000621538Q86SE8

Expression (GTEx)

0
10
20
30
40
50
60
70

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
369636202023Hexavalent chromium causes centrosome amplification by inhibiting the binding between TMOD2 and NPM2.0
369636202023Hexavalent chromium causes centrosome amplification by inhibiting the binding between TMOD2 and NPM2.0
362808412022Loss of NPM2 expression is a potential immunohistochemical marker for malignant peritoneal mesothelioma: a single-center study of 92 cases.2
362808412022Loss of NPM2 expression is a potential immunohistochemical marker for malignant peritoneal mesothelioma: a single-center study of 92 cases.2
223627532012Function of homo- and hetero-oligomers of human nucleoplasmin/nucleophosmin family proteins NPM1, NPM2 and NPM3 during sperm chromatin remodeling.31
229689122012Vertebrate nucleoplasmin and NASP: egg histone storage proteins with multiple chaperone activities.26
223627532012Function of homo- and hetero-oligomers of human nucleoplasmin/nucleophosmin family proteins NPM1, NPM2 and NPM3 during sperm chromatin remodeling.31
229689122012Vertebrate nucleoplasmin and NASP: egg histone storage proteins with multiple chaperone activities.26
205089832011Centrosome-related genes, genetic variation, and risk of breast cancer.21
218638212011Crystal structure and function of human nucleoplasmin (npm2): a histone chaperone in oocytes and embryos.25
205089832011Centrosome-related genes, genetic variation, and risk of breast cancer.21
218638212011Crystal structure and function of human nucleoplasmin (npm2): a histone chaperone in oocytes and embryos.25
194911932009Genome-wide screen of promoter methylation identifies novel markers in melanoma.103
194911932009Genome-wide screen of promoter methylation identifies novel markers in melanoma.103
122096032002Increased expression of a COOH-truncated nucleophosmin resulting from alternative splicing is associated with cellular resistance to ionizing radiation in HeLa cells.16

Citation

Dessen P

NPM2 (nucleophosmin/nucleoplasmin 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/70945/npm2-(nucleophosmin-nucleoplasmin-2)