NRDE2 (NRDE-2, necessary for RNA interference, domain containing)

2014-11-01  

Identity

HGNC
LOCATION
14q32.11
LOCUSID
ALIAS
C14orf102
FUSION GENES

Other Information

Locus ID:

NCBI: 55051
MIM: 618631
HGNC: 20186
Ensembl: ENSG00000119720

Variants:

dbSNP: 55051
ClinVar: 55051
TCGA: ENSG00000119720
COSMIC: NRDE2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000119720ENST00000354366Q9H7Z3
ENSG00000119720ENST00000553409G3V338
ENSG00000119720ENST00000554464H0YJT0
ENSG00000119720ENST00000556189H0YJT6
ENSG00000119720ENST00000628832G3V338

Expression (GTEx)

0
5
10
15

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
386971252024NRDE2 deficiency impairs homologous recombination repair and sensitizes hepatocellular carcinoma to PARP inhibitors.1
386971252024NRDE2 deficiency impairs homologous recombination repair and sensitizes hepatocellular carcinoma to PARP inhibitors.1
305381482019Human nuclear RNAi-defective 2 (NRDE2) is an essential RNA splicing factor.11
308422172019NRDE2 negatively regulates exosome functions by inhibiting MTR4 recruitment and exosome interaction.24
305381482019Human nuclear RNAi-defective 2 (NRDE2) is an essential RNA splicing factor.11
308422172019NRDE2 negatively regulates exosome functions by inhibiting MTR4 recruitment and exosome interaction.24
299021172018NRDE-2, the human homolog of fission yeast Nrl1, prevents DNA damage accumulation in human cells.12
299021172018NRDE-2, the human homolog of fission yeast Nrl1, prevents DNA damage accumulation in human cells.12

Citation

Dessen P

NRDE2 (NRDE-2, necessary for RNA interference, domain containing)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/70964/nrde2-(nrde-2-necessary-for-rna-interference-domain-containing)