NSDHL (NAD(P) dependent steroid dehydrogenase-like)

2014-11-01  

Identity

HGNC
LOCATION
Xq28
LOCUSID
ALIAS
H105E3,SDR31E1,XAP104
FUSION GENES

Other Information

Locus ID:

NCBI: 50814
MIM: 300275
HGNC: 13398
Ensembl: ENSG00000147383

Variants:

dbSNP: 50814
ClinVar: 50814
TCGA: ENSG00000147383
COSMIC: NSDHL

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000147383ENST00000370274Q15738
ENSG00000147383ENST00000370274A0A384NPZ7
ENSG00000147383ENST00000432467C9JDR0
ENSG00000147383ENST00000440023Q15738
ENSG00000147383ENST00000440023A0A384NPZ7

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Steroid biosynthesisKEGGko00100
Steroid biosynthesisKEGGhsa00100
Metabolic pathwaysKEGGhsa01100
Cholesterol biosynthesis, squalene 2,3-epoxide => cholesterolKEGGhsa_M00101
Cholesterol biosynthesis, squalene 2,3-epoxide => cholesterolKEGGM00101
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Cholesterol biosynthesisREACTOMER-HSA-191273

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
321407472021Crystal structures of human NSDHL and development of its novel inhibitor with the potential to suppress EGFR activity.8
331698342021CHILD syndrome in a Malaysian adult with identification of a novel heterozygous missense mutation NSDHL c.602A>G.1
332196172021NAD(P)-dependent steroid dehydrogenase-like protein and neutral cholesterol ester hydrolase 1 serve as novel markers for early detection of gastric cancer identified using quantitative proteomics.10
338641662021NSDHL promotes triple-negative breast cancer metastasis through the TGFβ signaling pathway and cholesterol biosynthesis.16
321407472021Crystal structures of human NSDHL and development of its novel inhibitor with the potential to suppress EGFR activity.8
331698342021CHILD syndrome in a Malaysian adult with identification of a novel heterozygous missense mutation NSDHL c.602A>G.1
332196172021NAD(P)-dependent steroid dehydrogenase-like protein and neutral cholesterol ester hydrolase 1 serve as novel markers for early detection of gastric cancer identified using quantitative proteomics.10
338641662021NSDHL promotes triple-negative breast cancer metastasis through the TGFβ signaling pathway and cholesterol biosynthesis.16
323662302020NAD(P)-dependent steroid dehydrogenase-like is involved in breast cancer cell growth and metastasis.9
323662302020NAD(P)-dependent steroid dehydrogenase-like is involved in breast cancer cell growth and metastasis.9
310785022019Identification of NSDHL mutations associated with CHILD syndrome in oral verruciform xanthoma.4
310785022019Identification of NSDHL mutations associated with CHILD syndrome in oral verruciform xanthoma.4
303768212018NSDHL-containing duplication at Xq28 in a male patient with autism spectrum disorder: a case report.2
303768212018NSDHL-containing duplication at Xq28 in a male patient with autism spectrum disorder: a case report.2
259003142015A novel missense mutation in the NSDHL gene identified in a Lithuanian family by targeted next-generation sequencing causes CK syndrome.1

Citation

Dessen P

NSDHL (NAD(P) dependent steroid dehydrogenase-like)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/70981/nsdhl-(nad(p)-dependent-steroid-dehydrogenase-like)