Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 221078
MIM: 617199
HGNC: 23529
Ensembl: ENSG00000241058
Variants:
dbSNP: 221078
ClinVar: 221078
TCGA: ENSG00000241058
COSMIC: NSUN6
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000241058 | ENST00000377304 | Q8TEA1 |
| ENSG00000241058 | ENST00000606425 | U3KQU2 |
| ENSG00000241058 | ENST00000607346 | A0A0D9SF14 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Gene Expression | REACTOME | R-HSA-74160 |
| tRNA processing | REACTOME | R-HSA-72306 |
| tRNA modification in the nucleus and cytosol | REACTOME | R-HSA-6782315 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38029727 | 2024 | NSUN6 Regulates NM23-H1 Expression in an m5C Manner to Affect Epithelial-Mesenchymal Transition in Lung Cancer. | 2 |
| 38029727 | 2024 | NSUN6 Regulates NM23-H1 Expression in an m5C Manner to Affect Epithelial-Mesenchymal Transition in Lung Cancer. | 2 |
| 37226891 | 2023 | Biallelic variants in NSUN6 cause an autosomal recessive neurodevelopmental disorder. | 2 |
| 37226891 | 2023 | Biallelic variants in NSUN6 cause an autosomal recessive neurodevelopmental disorder. | 2 |
| 33330931 | 2021 | Sequence- and structure-specific cytosine-5 mRNA methylation by NSUN6. | 70 |
| 33418496 | 2021 | The RNA methyltransferase NSUN6 suppresses pancreatic cancer development by regulating cell proliferation. | 42 |
| 34705606 | 2021 | NSUN6, an RNA methyltransferase of 5-mC controls glioblastoma response to temozolomide (TMZ) via NELFB and RPS6KB2 interaction. | 15 |
| 33330931 | 2021 | Sequence- and structure-specific cytosine-5 mRNA methylation by NSUN6. | 70 |
| 33418496 | 2021 | The RNA methyltransferase NSUN6 suppresses pancreatic cancer development by regulating cell proliferation. | 42 |
| 34705606 | 2021 | NSUN6, an RNA methyltransferase of 5-mC controls glioblastoma response to temozolomide (TMZ) via NELFB and RPS6KB2 interaction. | 15 |
| 28531330 | 2017 | Structural basis for substrate binding and catalytic mechanism of a human RNA:m5C methyltransferase NSun6. | 50 |
| 28531330 | 2017 | Structural basis for substrate binding and catalytic mechanism of a human RNA:m5C methyltransferase NSun6. | 50 |
| 27703015 | 2016 | Sequence-specific and Shape-selective RNA Recognition by the Human RNA 5-Methylcytosine Methyltransferase NSun6. | 21 |
| 27703015 | 2016 | Sequence-specific and Shape-selective RNA Recognition by the Human RNA 5-Methylcytosine Methyltransferase NSun6. | 21 |
| 26160102 | 2015 | NSUN6 is a human RNA methyltransferase that catalyzes formation of m5C72 in specific tRNAs. | 92 |
Citation
Dessen P
NSUN6 (NOP2/Sun RNA methyltransferase 6)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/70993/nsun6-(nop2-sun-rna-methyltransferase-6)
