NT5DC2 (5-nucleotidase domain containing 2)

2014-11-01  

Identity

HGNC
LOCATION
3p21.1
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 64943
HGNC: 25717
Ensembl: ENSG00000168268

Variants:

dbSNP: 64943
ClinVar: 64943
TCGA: ENSG00000168268
COSMIC: NT5DC2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168268ENST00000307076Q9H857
ENSG00000168268ENST00000422318Q9H857
ENSG00000168268ENST00000459839Q9H857
ENSG00000168268ENST00000463947H7C519
ENSG00000168268ENST00000471522C9J036
ENSG00000168268ENST00000489316H7C4G8
ENSG00000168268ENST00000492555F8WEY1

Expression (GTEx)

0
50
100
150

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
382891262024NT5DC2 knockdown suppresses progression, glycolysis, and neuropathic pain in triple-negative breast cancer by blocking the EGFR pathway.0
382891262024NT5DC2 knockdown suppresses progression, glycolysis, and neuropathic pain in triple-negative breast cancer by blocking the EGFR pathway.0
378008362023Gastric cancer metastasis-related NT5DC2 indicates unfavorable prognosis of patients.1
378008362023Gastric cancer metastasis-related NT5DC2 indicates unfavorable prognosis of patients.1
358941422022Decreased RNA‑binding protein IGF2BP2 downregulates NT5DC2, which suppresses cell proliferation, and induces cell cycle arrest and apoptosis in diffuse large B‑cell lymphoma cells by regulating the p53 signaling pathway.2
358941422022Decreased RNA‑binding protein IGF2BP2 downregulates NT5DC2, which suppresses cell proliferation, and induces cell cycle arrest and apoptosis in diffuse large B‑cell lymphoma cells by regulating the p53 signaling pathway.2
323820412020NT5DC2 promotes tumor cell proliferation by stabilizing EGFR in hepatocellular carcinoma.29
329628562020NT5DC2 suppression restrains progression towards metastasis of non-small-cell lung cancer through regulation p53 signaling.9
329918742020NT5DC2 knockdown inhibits colorectal carcinoma progression by repressing metastasis, angiogenesis and tumor-associated macrophage recruitment: A mechanism involving VEGF signaling.16
323820412020NT5DC2 promotes tumor cell proliferation by stabilizing EGFR in hepatocellular carcinoma.29
329628562020NT5DC2 suppression restrains progression towards metastasis of non-small-cell lung cancer through regulation p53 signaling.9
329918742020NT5DC2 knockdown inhibits colorectal carcinoma progression by repressing metastasis, angiogenesis and tumor-associated macrophage recruitment: A mechanism involving VEGF signaling.16
309784412019NT5DC2 promotes tumorigenicity of glioma stem-like cells by upregulating fyn.23
309784412019NT5DC2 promotes tumorigenicity of glioma stem-like cells by upregulating fyn.23

Citation

Dessen P

NT5DC2 (5-nucleotidase domain containing 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/71001/nt5dc2-(5-nucleotidase-domain-containing-2)