OPRL1 (opioid related nociceptin receptor 1)

2014-11-01 Affiliation

Identity

HGNC

OPRL1

LOCATION

20q13.33

LOCUSID

4987

ALIAS

KOR-3,KOR3,NOCIR,NOP,NOPr,OOR,OPRL,ORL1,PNOCR

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 4987
MIM: 602548
HGNC: 8155
Ensembl: ENSG00000125510

Variants:

dbSNP: 4987
ClinVar: 4987
TCGA: ENSG00000125510
COSMIC: OPRL1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000125510	ENST00000336866	P41146
ENSG00000125510	ENST00000349451	P41146
ENSG00000125510	ENST00000355631	P41146

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Neuroactive ligand-receptor interaction	KEGG	ko04080
Neuroactive ligand-receptor interaction	KEGG	hsa04080
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
Peptide ligand-binding receptors	REACTOME	R-HSA-375276
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (i) signalling events	REACTOME	R-HSA-418594

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA445043	Opioid-Related Disorders	Disease	ClinicalAnnotation, VariantAnnotation	associated		PD
PA452618	opioids	Chemical	ClinicalAnnotation, VariantAnnotation	associated		PD

References

Pubmed ID	Year	Title	Citations
37364634	2023	Heterodimerization of apelin and opioid receptor-like 1 receptors mediates apelin-13-induced G protein biased signaling.	0
37364634	2023	Heterodimerization of apelin and opioid receptor-like 1 receptors mediates apelin-13-induced G protein biased signaling.	0
30954231	2019	Decreased Nociceptin Receptors Are Related to Resilience and Recovery in College Women Who Have Experienced Sexual Violence: Therapeutic Implications for Posttraumatic Stress Disorder.	10
30954231	2019	Decreased Nociceptin Receptors Are Related to Resilience and Recovery in College Women Who Have Experienced Sexual Violence: Therapeutic Implications for Posttraumatic Stress Disorder.	10
29197086	2018	Methylation of OPRL1 mediates the effect of psychosocial stress on binge drinking in adolescents.	5
29615517	2018	The nociceptin receptor inhibits axonal regeneration and recovery from spinal cord injury.	9
30152845	2018	Elevated methylation of OPRM1 and OPRL1 genes in Alzheimer's disease.	9
30255608	2018	Nociceptin/orphanin FQ opioid peptide-receptor expression in pachyonychia congenita.	5
29197086	2018	Methylation of OPRL1 mediates the effect of psychosocial stress on binge drinking in adolescents.	5
29615517	2018	The nociceptin receptor inhibits axonal regeneration and recovery from spinal cord injury.	9
30152845	2018	Elevated methylation of OPRM1 and OPRL1 genes in Alzheimer's disease.	9
30255608	2018	Nociceptin/orphanin FQ opioid peptide-receptor expression in pachyonychia congenita.	5
27271345	2016	Specific affinity-labeling of the nociceptin ORL1 receptor using a thiol-activated Cys(Npys)-containing peptide ligand.	1
27490265	2016	Pharmacogenetics of cystic fibrosis treatment.	3
27271345	2016	Specific affinity-labeling of the nociceptin ORL1 receptor using a thiol-activated Cys(Npys)-containing peptide ligand.	1

Citation

Dessen P

OPRL1 (opioid related nociceptin receptor 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/71137/oprl1-(opioid-related-nociceptin-receptor-1)