Identity
HGNC
LOCATION
20q13.33
LOCUSID
ALIAS
KOR-3,KOR3,NOCIR,NOP,NOPr,OOR,OPRL,ORL1,PNOCR
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 4987
MIM: 602548
HGNC: 8155
Ensembl: ENSG00000125510
Variants:
dbSNP: 4987
ClinVar: 4987
TCGA: ENSG00000125510
COSMIC: OPRL1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000125510 | ENST00000336866 | P41146 |
| ENSG00000125510 | ENST00000349451 | P41146 |
| ENSG00000125510 | ENST00000355631 | P41146 |
Expression (GTEx)
Pathways
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA445043 | Opioid-Related Disorders | Disease | ClinicalAnnotation, VariantAnnotation | associated | PD | ||
| PA452618 | opioids | Chemical | ClinicalAnnotation, VariantAnnotation | associated | PD |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37364634 | 2023 | Heterodimerization of apelin and opioid receptor-like 1 receptors mediates apelin-13-induced G protein biased signaling. | 0 |
| 37364634 | 2023 | Heterodimerization of apelin and opioid receptor-like 1 receptors mediates apelin-13-induced G protein biased signaling. | 0 |
| 30954231 | 2019 | Decreased Nociceptin Receptors Are Related to Resilience and Recovery in College Women Who Have Experienced Sexual Violence: Therapeutic Implications for Posttraumatic Stress Disorder. | 10 |
| 30954231 | 2019 | Decreased Nociceptin Receptors Are Related to Resilience and Recovery in College Women Who Have Experienced Sexual Violence: Therapeutic Implications for Posttraumatic Stress Disorder. | 10 |
| 29197086 | 2018 | Methylation of OPRL1 mediates the effect of psychosocial stress on binge drinking in adolescents. | 5 |
| 29615517 | 2018 | The nociceptin receptor inhibits axonal regeneration and recovery from spinal cord injury. | 9 |
| 30152845 | 2018 | Elevated methylation of OPRM1 and OPRL1 genes in Alzheimer's disease. | 9 |
| 30255608 | 2018 | Nociceptin/orphanin FQ opioid peptide-receptor expression in pachyonychia congenita. | 5 |
| 29197086 | 2018 | Methylation of OPRL1 mediates the effect of psychosocial stress on binge drinking in adolescents. | 5 |
| 29615517 | 2018 | The nociceptin receptor inhibits axonal regeneration and recovery from spinal cord injury. | 9 |
| 30152845 | 2018 | Elevated methylation of OPRM1 and OPRL1 genes in Alzheimer's disease. | 9 |
| 30255608 | 2018 | Nociceptin/orphanin FQ opioid peptide-receptor expression in pachyonychia congenita. | 5 |
| 27271345 | 2016 | Specific affinity-labeling of the nociceptin ORL1 receptor using a thiol-activated Cys(Npys)-containing peptide ligand. | 1 |
| 27490265 | 2016 | Pharmacogenetics of cystic fibrosis treatment. | 3 |
| 27271345 | 2016 | Specific affinity-labeling of the nociceptin ORL1 receptor using a thiol-activated Cys(Npys)-containing peptide ligand. | 1 |
Citation
Dessen P
OPRL1 (opioid related nociceptin receptor 1)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/71137/oprl1-(opioid-related-nociceptin-receptor-1)
