OPTC (opticin)

2014-11-01  

Identity

HGNC
OPTC
LOCATION
1q32.1
LOCUSID
26254
ALIAS
OPT

Other Information

Locus ID:

NCBI: 26254
MIM: 605127
HGNC: 8158
Ensembl: ENSG00000188770

Variants:

dbSNP: 26254
ClinVar: 26254
TCGA: ENSG00000188770
COSMIC: OPTC

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000188770ENST00000367222Q9UBM4
ENSG00000188770ENST00000448911Q5T2G3

Expression (GTEx)

0
1
2
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Extracellular matrix organizationREACTOMER-HSA-1474244
Degradation of the extracellular matrixREACTOMER-HSA-1474228

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
eye
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
338112212021An interplay of microglia and matrix metalloproteinase MMP9 under hypoxic stress regulates the opticin expression in retina.7
338112212021An interplay of microglia and matrix metalloproteinase MMP9 under hypoxic stress regulates the opticin expression in retina.7
225341132012Opticin production is reduced by hypoxia and VEGF in human retinal pigment epithelium via MMP-2 activation.7
226699772012Opticin exerts its anti-angiogenic activity by regulating extracellular matrix adhesiveness.24
225341132012Opticin production is reduced by hypoxia and VEGF in human retinal pigment epithelium via MMP-2 activation.7
226699772012Opticin exerts its anti-angiogenic activity by regulating extracellular matrix adhesiveness.24
202019262010Human variation in alcohol response is influenced by variation in neuronal signaling genes.52
202019262010Human variation in alcohol response is influenced by variation in neuronal signaling genes.52
195361752009Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study.32
198445862009An evaluation of OPTC and EPYC as candidate genes for high myopia.8
198445862009An evaluation of OPTC and EPYC as candidate genes for high myopia.8
195361752009Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study.32
198445862009An evaluation of OPTC and EPYC as candidate genes for high myopia.8
198445862009An evaluation of OPTC and EPYC as candidate genes for high myopia.8
173595252007Evaluation of the OPTC gene in primary open angle glaucoma: functional significance of a silent change.16

Citation

Dessen P

OPTC (opticin)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/71138/optc-(opticin)