Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 26254
MIM: 605127
HGNC: 8158
Ensembl: ENSG00000188770
Variants:
dbSNP: 26254
ClinVar: 26254
TCGA: ENSG00000188770
COSMIC: OPTC
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000188770 | ENST00000367222 | Q9UBM4 |
| ENSG00000188770 | ENST00000448911 | Q5T2G3 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Extracellular matrix organization | REACTOME | R-HSA-1474244 |
| Degradation of the extracellular matrix | REACTOME | R-HSA-1474228 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 33811221 | 2021 | An interplay of microglia and matrix metalloproteinase MMP9 under hypoxic stress regulates the opticin expression in retina. | 7 |
| 33811221 | 2021 | An interplay of microglia and matrix metalloproteinase MMP9 under hypoxic stress regulates the opticin expression in retina. | 7 |
| 22534113 | 2012 | Opticin production is reduced by hypoxia and VEGF in human retinal pigment epithelium via MMP-2 activation. | 7 |
| 22669977 | 2012 | Opticin exerts its anti-angiogenic activity by regulating extracellular matrix adhesiveness. | 24 |
| 22534113 | 2012 | Opticin production is reduced by hypoxia and VEGF in human retinal pigment epithelium via MMP-2 activation. | 7 |
| 22669977 | 2012 | Opticin exerts its anti-angiogenic activity by regulating extracellular matrix adhesiveness. | 24 |
| 20201926 | 2010 | Human variation in alcohol response is influenced by variation in neuronal signaling genes. | 52 |
| 20201926 | 2010 | Human variation in alcohol response is influenced by variation in neuronal signaling genes. | 52 |
| 19536175 | 2009 | Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. | 32 |
| 19844586 | 2009 | An evaluation of OPTC and EPYC as candidate genes for high myopia. | 8 |
| 19844586 | 2009 | An evaluation of OPTC and EPYC as candidate genes for high myopia. | 8 |
| 19536175 | 2009 | Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. | 32 |
| 19844586 | 2009 | An evaluation of OPTC and EPYC as candidate genes for high myopia. | 8 |
| 19844586 | 2009 | An evaluation of OPTC and EPYC as candidate genes for high myopia. | 8 |
| 17359525 | 2007 | Evaluation of the OPTC gene in primary open angle glaucoma: functional significance of a silent change. | 16 |
Citation
Dessen P
OPTC (opticin)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/71138/optc-(opticin)
