P2RY4 (pyrimidinergic receptor P2Y4)

2014-11-01  

Identity

HGNC
P2RY4
LOCATION
Xq13.1
LOCUSID
5030
ALIAS
NRU,P2P,P2Y4,UNR

Other Information

Locus ID:

NCBI: 5030
MIM: 300038
HGNC: 8542
Ensembl: ENSG00000186912

Variants:

dbSNP: 5030
ClinVar: 5030
TCGA: ENSG00000186912
COSMIC: P2RY4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000186912ENST00000374519P51582

Expression (GTEx)

0
1
2
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Taste transductionKEGGko04742
Neuroactive ligand-receptor interactionKEGGhsa04080
Taste transductionKEGGhsa04742
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Nucleotide-like (purinergic) receptorsREACTOMER-HSA-418038
P2Y receptorsREACTOMER-HSA-417957
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
250032382014Expression of astrocyte-related receptors in cortical dysplasia with intractable epilepsy.10
250032382014Expression of astrocyte-related receptors in cortical dysplasia with intractable epilepsy.10
220525572012Purinergic receptors expressed in human skeletal muscle fibres.9
227769022012Trauma-induced expression of astrocytic thrombospondin-1 is regulated by P2 receptors coupled to protein kinase cascades.11
220525572012Purinergic receptors expressed in human skeletal muscle fibres.9
227769022012Trauma-induced expression of astrocytic thrombospondin-1 is regulated by P2 receptors coupled to protein kinase cascades.11
212193312011Proteinase-activated receptors, nucleotide P2Y receptors, and μ-opioid receptor-1B are under the control of the type I transmembrane proteins p23 and p24A in post-Golgi trafficking.13
212193312011Proteinase-activated receptors, nucleotide P2Y receptors, and μ-opioid receptor-1B are under the control of the type I transmembrane proteins p23 and p24A in post-Golgi trafficking.13
156497002005The metabotropic P2Y4 receptor participates in the commitment to differentiation and cell death of human neuroblastoma SH-SY5Y cells.9
156497002005The metabotropic P2Y4 receptor participates in the commitment to differentiation and cell death of human neuroblastoma SH-SY5Y cells.9
146709662004Agonist versus antagonist action of ATP at the P2Y4 receptor is determined by the second extracellular loop.15
146709662004Agonist versus antagonist action of ATP at the P2Y4 receptor is determined by the second extracellular loop.15
126038582003Human keratinocytes express multiple P2Y-receptors: evidence for functional P2Y1, P2Y2, and P2Y4 receptors.16
126231232003Tumor necrosis factor alpha-induced apoptosis in astrocytes is prevented by the activation of P2Y6, but not P2Y4 nucleotide receptors.21
126038582003Human keratinocytes express multiple P2Y-receptors: evidence for functional P2Y1, P2Y2, and P2Y4 receptors.16

Citation

Dessen P

P2RY4 (pyrimidinergic receptor P2Y4)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/71608/p2ry4-(pyrimidinergic-receptor-p2y4)