Identity
HGNC
LOCATION
1p36.13
LOCUSID
ALIAS
HPAD10,PAD1,PDI,PDI1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 29943
MIM: 607934
HGNC: 18367
Ensembl: ENSG00000142623
Variants:
dbSNP: 29943
ClinVar: 29943
TCGA: ENSG00000142623
COSMIC: PADI1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000142623 | ENST00000375471 | Q9ULC6 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Chromatin organization | REACTOME | R-HSA-4839726 |
| Chromatin modifying enzymes | REACTOME | R-HSA-3247509 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 34352263 | 2022 | IL-22 Downregulates Peptidylarginine Deiminase-1 in Human Keratinocytes: Adding Another Piece to the IL-22 Puzzle in Epidermal Barrier Formation. | 8 |
| 34352263 | 2022 | IL-22 Downregulates Peptidylarginine Deiminase-1 in Human Keratinocytes: Adding Another Piece to the IL-22 Puzzle in Epidermal Barrier Formation. | 8 |
| 33741961 | 2021 | Citrullination of pyruvate kinase M2 by PADI1 and PADI3 regulates glycolysis and cancer cell proliferation. | 21 |
| 33741961 | 2021 | Citrullination of pyruvate kinase M2 by PADI1 and PADI3 regulates glycolysis and cancer cell proliferation. | 21 |
| 31952341 | 2020 | Deimination and Peptidylarginine Deiminases in Skin Physiology and Diseases. | 32 |
| 31952341 | 2020 | Deimination and Peptidylarginine Deiminases in Skin Physiology and Diseases. | 32 |
| 28844713 | 2017 | PAD1 promotes epithelial-mesenchymal transition and metastasis in triple-negative breast cancer cells by regulating MEK1-ERK1/2-MMP2 signaling. | 45 |
| 28844713 | 2017 | PAD1 promotes epithelial-mesenchymal transition and metastasis in triple-negative breast cancer cells by regulating MEK1-ERK1/2-MMP2 signaling. | 45 |
| 26616205 | 2016 | Acefylline activates filaggrin deimination by peptidylarginine deiminases in the upper epidermis. | 7 |
| 26616205 | 2016 | Acefylline activates filaggrin deimination by peptidylarginine deiminases in the upper epidermis. | 7 |
| 20596086 | 2010 | An intronic enhancer driven by NF-κB contributes to transcriptional regulation of peptidylarginine deiminase type I gene in human keratinocytes. | 13 |
| 20596086 | 2010 | An intronic enhancer driven by NF-κB contributes to transcriptional regulation of peptidylarginine deiminase type I gene in human keratinocytes. | 13 |
| 17851584 | 2008 | Crucial roles of MZF1 and Sp1 in the transcriptional regulation of the peptidylarginine deiminase type I gene (PADI1) in human keratinocytes. | 12 |
| 18669583 | 2008 | Gene expression profiling identifies genes predictive of oral squamous cell carcinoma. | 132 |
| 18710930 | 2008 | Citrullination of CXCL8 by peptidylarginine deiminase alters receptor usage, prevents proteolysis, and dampens tissue inflammation. | 77 |
Citation
Dessen P
PADI1 (peptidyl arginine deiminase 1)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/71626/padi1-(peptidyl-arginine-deiminase-1)
