PAN2 (poly(A) specific ribonuclease subunit PAN2)

2014-11-01  

Identity

HGNC
LOCATION
12q13.3
LOCUSID
ALIAS
USP52
FUSION GENES

Other Information

Locus ID:

NCBI: 9924
MIM: 617447
HGNC: 20074
Ensembl: ENSG00000135473

Variants:

dbSNP: 9924
ClinVar: 9924
TCGA: ENSG00000135473
COSMIC: PAN2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135473ENST00000257931Q504Q3
ENSG00000135473ENST00000425394Q504Q3
ENSG00000135473ENST00000440411Q504Q3
ENSG00000135473ENST00000547572F8VXK8
ENSG00000135473ENST00000548043Q504Q3
ENSG00000135473ENST00000610546Q504Q3

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
RNA degradationKEGGko03018
RNA degradationKEGGhsa03018
Gene ExpressionREACTOMER-HSA-74160
Deadenylation-dependent mRNA decayREACTOMER-HSA-429914
Deadenylation of mRNAREACTOMER-HSA-429947

References

Pubmed IDYearTitleCitations
353046022022Biallelic PAN2 variants in individuals with a syndromic neurodevelopmental disorder and multiple congenital anomalies.3
353046022022Biallelic PAN2 variants in individuals with a syndromic neurodevelopmental disorder and multiple congenital anomalies.3
345331982021USP52 inhibits cell proliferation by stabilizing PTEN protein in non-small cell lung cancer.2
345331982021USP52 inhibits cell proliferation by stabilizing PTEN protein in non-small cell lung cancer.2
330977102020USP52 regulates DNA end resection and chemosensitivity through removing inhibitory ubiquitination from CtIP.14
330977102020USP52 regulates DNA end resection and chemosensitivity through removing inhibitory ubiquitination from CtIP.14
295994862018USP52 acts as a deubiquitinase and promotes histone chaperone ASF1A stabilization.20
295994862018USP52 acts as a deubiquitinase and promotes histone chaperone ASF1A stabilization.20
233984562013The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability.34
233984562013The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability.34
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.15
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.15
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.105
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.105
145836022004Identification of a human cytoplasmic poly(A) nuclease complex stimulated by poly(A)-binding protein.53

Citation

Dessen P

PAN2 (poly(A) specific ribonuclease subunit PAN2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/71644/teaching-explorer/welcome