PANK1 (pantothenate kinase 1)

2014-11-01  

Identity

HGNC
LOCATION
10q23.31
LOCUSID
ALIAS
PANK
FUSION GENES

Other Information

Locus ID:

NCBI: 53354
MIM: 606160
HGNC: 8598
Ensembl: ENSG00000152782

Variants:

dbSNP: 53354
ClinVar: 53354
TCGA: ENSG00000152782
COSMIC: PANK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000152782ENST00000307534Q8TE04
ENSG00000152782ENST00000322191Q8TE04
ENSG00000152782ENST00000342512Q8TE04

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Pantothenate and CoA biosynthesisKEGGko00770
Pantothenate and CoA biosynthesisKEGGhsa00770
Metabolic pathwaysKEGGhsa01100
Coenzyme A biosynthesis, pantothenate => CoAKEGGhsa_M00120
Coenzyme A biosynthesis, pantothenate => CoAKEGGM00120
MetabolismREACTOMER-HSA-1430728
Metabolism of vitamins and cofactorsREACTOMER-HSA-196854
Metabolism of water-soluble vitamins and cofactorsREACTOMER-HSA-196849
Vitamin B5 (pantothenate) metabolismREACTOMER-HSA-199220
Coenzyme A biosynthesisREACTOMER-HSA-196783

References

Pubmed IDYearTitleCitations
371384302024Expression and Prognostic Role of PANK1 in Glioma.0
371384302024Expression and Prognostic Role of PANK1 in Glioma.0
352806712022Pantothenate Kinase 1 Inhibits the Progression of Hepatocellular Carcinoma by Negatively Regulating Wnt/β-catenin Signaling.4
352806712022Pantothenate Kinase 1 Inhibits the Progression of Hepatocellular Carcinoma by Negatively Regulating Wnt/β-catenin Signaling.4
233437622013p53-Dependent regulation of metabolic function through transcriptional activation of pantothenate kinase-1 gene.35
233437622013p53-Dependent regulation of metabolic function through transcriptional activation of pantothenate kinase-1 gene.35
229128112012Cofilin/Twinstar phosphorylation levels increase in response to impaired coenzyme a metabolism.7
229128112012Cofilin/Twinstar phosphorylation levels increase in response to impaired coenzyme a metabolism.7
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
190609102009Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.388
190609102009Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.388
176315022007Crystal structures of human pantothenate kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorder.42
176315022007Crystal structures of human pantothenate kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorder.42
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.83

Citation

Dessen P

PANK1 (pantothenate kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/71647/pank1-(pantothenate-kinase-1)