PATL1 (PAT1 homolog 1, processing body mRNA decay factor)

2014-11-01 Affiliation

Identity

HGNC

PATL1

LOCATION

11q12.1

LOCUSID

219988

ALIAS

Pat1b,hPat1b

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 219988
MIM: 614660
HGNC: 26721
Ensembl: ENSG00000166889

Variants:

dbSNP: 219988
ClinVar: 219988
TCGA: ENSG00000166889
COSMIC: PATL1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000166889	ENST00000300146	Q86TB9

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
RNA degradation	KEGG	ko03018
RNA degradation	KEGG	hsa03018
Decapping complex	KEGG	hsa_M00395
Decapping complex	KEGG	M00395
Gene Expression	REACTOME	R-HSA-74160
Deadenylation-dependent mRNA decay	REACTOME	R-HSA-429914
mRNA decay by 5' to 3' exoribonuclease	REACTOME	R-HSA-430039

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
31340047	2019	A low-complexity region in human XRN1 directly recruits deadenylation and decapping factors in 5'-3' messenger RNA decay.	19
31340047	2019	A low-complexity region in human XRN1 directly recruits deadenylation and decapping factors in 5'-3' messenger RNA decay.	19
28768202	2017	Dual RNA Processing Roles of Pat1b via Cytoplasmic Lsm1-7 and Nuclear Lsm2-8 Complexes.	18
28768202	2017	Dual RNA Processing Roles of Pat1b via Cytoplasmic Lsm1-7 and Nuclear Lsm2-8 Complexes.	18
23535175	2013	Role of Rck-Pat1b binding in assembly of processing-bodies.	13
23535175	2013	Role of Rck-Pat1b binding in assembly of processing-bodies.	13
22090346	2012	RNA-related nuclear functions of human Pat1b, the P-body mRNA decay factor.	21
22437941	2012	Identification of the P-body component PATL1 as a novel ALG-2-interacting protein by in silico and far-Western screening of proline-rich proteins.	9
22090346	2012	RNA-related nuclear functions of human Pat1b, the P-body mRNA decay factor.	21
22437941	2012	Identification of the P-body component PATL1 as a novel ALG-2-interacting protein by in silico and far-Western screening of proline-rich proteins.	9
20852261	2011	The human Pat1b protein: a novel mRNA deadenylation factor identified by a new immunoprecipitation technique.	23
20852261	2011	The human Pat1b protein: a novel mRNA deadenylation factor identified by a new immunoprecipitation technique.	23
20543818	2010	The C-terminal alpha-alpha superhelix of Pat is required for mRNA decapping in metazoa.	35
20584987	2010	Human Pat1b connects deadenylation with mRNA decapping and controls the assembly of processing bodies.	81
20826699	2010	Distinct functions of maternal and somatic Pat1 protein paralogs.	35

Citation

Dessen P

PATL1 (PAT1 homolog 1, processing body mRNA decay factor)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/71678/js/hgnc