PCIF1 (phosphorylated CTD interacting factor 1)

2014-11-01  

Identity

HGNC
PCIF1
LOCATION
20q13.12
LOCUSID
63935
ALIAS
C20orf67,CAPAM,PPP1R121,hCAPAM,hPCIF1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 63935
MIM: 618626
HGNC: 16200
Ensembl: ENSG00000100982

Variants:

dbSNP: 63935
ClinVar: 63935
TCGA: ENSG00000100982
COSMIC: PCIF1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100982ENST00000372409Q9H4Z3
ENSG00000100982ENST00000479348A0A087WWZ2

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
385263252024m6Am methyltransferase PCIF1 negatively regulates ciliation by inhibiting BICD2 expression.1
385263252024m6Am methyltransferase PCIF1 negatively regulates ciliation by inhibiting BICD2 expression.1
365149402023Role of PCIF1-mediated 5'-cap N6-methyladeonsine mRNA methylation in colorectal cancer and anti-PD-1 immunotherapy.8
376430072023The CTBP2-PCIF1 complex regulates m6Am modification of mRNA in head and neck squamous cell carcinoma.2
365149402023Role of PCIF1-mediated 5'-cap N6-methyladeonsine mRNA methylation in colorectal cancer and anti-PD-1 immunotherapy.8
376430072023The CTBP2-PCIF1 complex regulates m6Am modification of mRNA in head and neck squamous cell carcinoma.2
351891462022Enzymatic characterization of mRNA cap adenosine-N6 methyltransferase PCIF1 activity on uncapped RNAs.8
358684832022Effects of the m6Am methyltransferase PCIF1 on cell proliferation and survival in gliomas.5
351891462022Enzymatic characterization of mRNA cap adenosine-N6 methyltransferase PCIF1 activity on uncapped RNAs.8
358684832022Effects of the m6Am methyltransferase PCIF1 on cell proliferation and survival in gliomas.5
334289442021Enzymatic characterization of three human RNA adenosine methyltransferases reveals diverse substrate affinities and reaction optima.18
342669512021Methylation of viral mRNA cap structures by PCIF1 attenuates the antiviral activity of interferon-β.19
345450782021HIV reprograms host m(6)Am RNA methylome by viral Vpr protein-mediated degradation of PCIF1.22
346348062021The comprehensive interactomes of human adenosine RNA methyltransferases and demethylases reveal distinct functional and regulatory features.21
334289442021Enzymatic characterization of three human RNA adenosine methyltransferases reveals diverse substrate affinities and reaction optima.18

Citation

Dessen P

PCIF1 (phosphorylated CTD interacting factor 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/71761/pcif1-(phosphorylated-ctd-interacting-factor-1)