Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 375033
MIM: 610278
HGNC: 33631
Ensembl: ENSG00000187800
Variants:
dbSNP: 375033
ClinVar: 375033
TCGA: ENSG00000187800
COSMIC: PEAR1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000187800 | ENST00000292357 | Q5VY43 |
| ENSG00000187800 | ENST00000338302 | Q5VY43 |
| ENSG00000187800 | ENST00000444016 | F2Z2F7 |
| ENSG00000187800 | ENST00000455314 | A6PVP2 |
Expression (GTEx)
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA154410481 | prasugrel | Chemical | ClinicalAnnotation | associated | PD | 23859572, 28820077 | |
| PA165374673 | ticagrelor | Chemical | ClinicalAnnotation | associated | PD | 27937053 | |
| PA445019 | Myocardial Infarction | Disease | ClinicalAnnotation | associated | PD | 23392654 | |
| PA448497 | aspirin | Chemical | ClinicalAnnotation | associated | PD | 23392654, 23859572, 28820077 | |
| PA449053 | clopidogrel | Chemical | ClinicalAnnotation | associated | PD | 23392654, 26962983, 28820077 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36436185 | 2023 | PEAR1 is a potential regulator of early hematopoiesis of human pluripotent stem cells. | 1 |
| 36436185 | 2023 | PEAR1 is a potential regulator of early hematopoiesis of human pluripotent stem cells. | 1 |
| 32445063 | 2021 | PEAR1 polymorphisms as a prognostic factor in hemostasis and cardiovascular diseases. | 8 |
| 34075782 | 2021 | Genetic variants of PEAR1 and ischemic clinical outcomes in coronary artery disease patients: a systematic review and meta-analysis. | 3 |
| 32445063 | 2021 | PEAR1 polymorphisms as a prognostic factor in hemostasis and cardiovascular diseases. | 8 |
| 34075782 | 2021 | Genetic variants of PEAR1 and ischemic clinical outcomes in coronary artery disease patients: a systematic review and meta-analysis. | 3 |
| 31678362 | 2020 | PEAR1 suppresses the proliferation of pulmonary microvascular endothelial cells via PI3K/AKT pathway in ALI model. | 7 |
| 32541641 | 2020 | Lower Platelet Aggregation Is a Risk Factor for Dual Antiplatelet Therapy-Associated Bleeding: A Preliminary Retrospective Study with Genotype Analysis. | 0 |
| 32562573 | 2020 | Genetic Variation in PEAR1, Cardiovascular Outcomes and Effects of Aspirin in a Healthy Elderly Population. | 12 |
| 31678362 | 2020 | PEAR1 suppresses the proliferation of pulmonary microvascular endothelial cells via PI3K/AKT pathway in ALI model. | 7 |
| 32541641 | 2020 | Lower Platelet Aggregation Is a Risk Factor for Dual Antiplatelet Therapy-Associated Bleeding: A Preliminary Retrospective Study with Genotype Analysis. | 0 |
| 32562573 | 2020 | Genetic Variation in PEAR1, Cardiovascular Outcomes and Effects of Aspirin in a Healthy Elderly Population. | 12 |
| 30256383 | 2019 | A PEAR1 polymorphism (rs12041331) is associated with risk of coronary artery aneurysm in Kawasaki disease. | 8 |
| 30700416 | 2019 | Synthetic glycopolymers and natural fucoidans cause human platelet aggregation via PEAR1 and GPIbα. | 10 |
| 31018667 | 2019 | Impact of Platelet Endothelial Aggregation Receptor-1 Genotypes on Platelet Reactivity and Early Cardiovascular Outcomes in Patients Undergoing Percutaneous Coronary Intervention and Treated With Aspirin and Clopidogrel. | 11 |
Citation
Dessen P
PEAR1 (platelet endothelial aggregation receptor 1)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/71822/pear1-(platelet-endothelial-aggregation-receptor-1)
