Identity
HGNC
LOCATION
17p13.1
LOCUSID
ALIAS
C17orf38,HsT41028,p84 PIKAP,p87(PIKAP),p87PIKAP
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 146850
MIM: 611462
HGNC: 27101
Ensembl: ENSG00000276231
Variants:
dbSNP: 146850
ClinVar: 146850
TCGA: ENSG00000276231
COSMIC: PIK3R6
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000276231 | ENST00000611951 | A0A087X1F3 |
| ENSG00000276231 | ENST00000613555 | A0A087X1F3 |
| ENSG00000276231 | ENST00000619866 | Q5UE93 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38831518 | 2024 | Knockdown of PIK3R6 impedes the onset and advancement of clear cell renal cell carcinoma. | 0 |
| 38831518 | 2024 | Knockdown of PIK3R6 impedes the onset and advancement of clear cell renal cell carcinoma. | 0 |
| 37708538 | 2023 | PIK3R6 Promotes Angiogenesis in Hepatocellular carcinoma by Activating STAT3 Signaling Pathway. | 1 |
| 37708538 | 2023 | PIK3R6 Promotes Angiogenesis in Hepatocellular carcinoma by Activating STAT3 Signaling Pathway. | 1 |
| 33155192 | 2020 | RBBP6 aggravates the progression of ovarian cancer by targeting PIK3R6. | 2 |
| 33155192 | 2020 | RBBP6 aggravates the progression of ovarian cancer by targeting PIK3R6. | 2 |
| 25753393 | 2015 | p84 forms a negative regulatory complex with p110γ to control PI3Kγ signalling during cell migration. | 3 |
| 25753393 | 2015 | p84 forms a negative regulatory complex with p110γ to control PI3Kγ signalling during cell migration. | 3 |
| 24014027 | 2013 | p87 and p101 subunits are distinct regulators determining class IB phosphoinositide 3-kinase (PI3K) specificity. | 20 |
| 24014027 | 2013 | p87 and p101 subunits are distinct regulators determining class IB phosphoinositide 3-kinase (PI3K) specificity. | 20 |
| 21996737 | 2012 | Differential roles for the p101 and p84 regulatory subunits of PI3Kγ in tumor growth and metastasis. | 29 |
| 22728827 | 2012 | GPCR activation of Ras and PI3Kc in neutrophils depends on PLCb2/b3 and the RasGEF RasGRP4. | 31 |
| 21996737 | 2012 | Differential roles for the p101 and p84 regulatory subunits of PI3Kγ in tumor growth and metastasis. | 29 |
| 22728827 | 2012 | GPCR activation of Ras and PI3Kc in neutrophils depends on PLCb2/b3 and the RasGEF RasGRP4. | 31 |
| 18323525 | 2008 | Phosphatidylinositol-3-kinase-gamma is integral to homing functions of progenitor cells. | 16 |
Citation
Dessen P
PIK3R6 (phosphoinositide-3-kinase regulatory subunit 6)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/71919/pik3r6-(phosphoinositide-3-kinase-regulatory-subunit-6)
