PLA2G12A (phospholipase A2 group XIIA)

Identity

HGNC

PLA2G12A

LOCATION

4q25

LOCUSID

81579

ALIAS

GXII,PLA2G12,ROSSY

FUSION GENES

Show Gene Fusions

Other Information

Locus ID:

NCBI: 81579
MIM: 611652
HGNC: 18554
Ensembl: ENSG00000123739

Variants:

dbSNP: 81579
ClinVar: 81579
TCGA: ENSG00000123739
COSMIC: PLA2G12A

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000123739	ENST00000243501	Q9BZM1
ENSG00000123739	ENST00000243501	Q542Y6
ENSG00000123739	ENST00000502283	A0A0C4DGC6
ENSG00000123739	ENST00000507961	D6RBP5

Expression (GTEx)

0

5

10

15

20

25

30

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Acyl chain remodelling of PC	REACTOME	R-HSA-1482788
Acyl chain remodelling of PE	REACTOME	R-HSA-1482839
Acyl chain remodelling of PG	REACTOME	R-HSA-1482925
Acyl chain remodelling of PI	REACTOME	R-HSA-1482922
Acyl chain remodelling of PS	REACTOME	R-HSA-1482801
alpha-Linolenic acid metabolism	KEGG	ko00592
alpha-Linolenic acid metabolism	KEGG	hsa00592
Arachidonic acid metabolism	KEGG	ko00590
Arachidonic acid metabolism	KEGG	hsa00590
Ether lipid metabolism	KEGG	ko00565

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Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
12522102	2003	Cellular arachidonate-releasing function of novel classes of secretory phospholipase A2s (groups III and XII).	30
19773279	2009	Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity.	9
19773279	2009	Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity.	9
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	105
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	105
20332099	2010	A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts.	8
20332099	2010	A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts.	8
20628086	2010	Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.	15
20628086	2010	Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.	15
27434078	2016	Association between PLA2G12A Polymorphisms and Schizophrenia in a Han Chinese Population from Northeast China.	5

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Citation

Dessen P

PLA2G12A (phospholipase A2 group XIIA)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/71950/pla2g12a-(phospholipase-a2-group-xiia)