PLA2G12A (phospholipase A2 group XIIA)

2014-11-01  

Identity

HGNC
PLA2G12A
LOCATION
4q25
LOCUSID
81579
ALIAS
GXII,PLA2G12,ROSSY
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 81579
MIM: 611652
HGNC: 18554
Ensembl: ENSG00000123739

Variants:

dbSNP: 81579
ClinVar: 81579
TCGA: ENSG00000123739
COSMIC: PLA2G12A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000123739ENST00000243501Q9BZM1
ENSG00000123739ENST00000243501Q542Y6
ENSG00000123739ENST00000502283A0A0C4DGC6
ENSG00000123739ENST00000507961D6RBP5

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glycerophospholipid metabolismKEGGko00564
Ether lipid metabolismKEGGko00565
Arachidonic acid metabolismKEGGko00590
Linoleic acid metabolismKEGGko00591
alpha-Linolenic acid metabolismKEGGko00592
Glycerophospholipid metabolismKEGGhsa00564
Ether lipid metabolismKEGGhsa00565
Arachidonic acid metabolismKEGGhsa00590
Linoleic acid metabolismKEGGhsa00591
alpha-Linolenic acid metabolismKEGGhsa00592
Vascular smooth muscle contractionKEGGhsa04270
Vascular smooth muscle contractionKEGGko04270
Metabolic pathwaysKEGGhsa01100
Pancreatic secretionKEGGko04972
Pancreatic secretionKEGGhsa04972
Fat digestion and absorptionKEGGko04975
Fat digestion and absorptionKEGGhsa04975
Ras signaling pathwayKEGGhsa04014
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Phospholipid metabolismREACTOMER-HSA-1483257
Glycerophospholipid biosynthesisREACTOMER-HSA-1483206
Synthesis of PAREACTOMER-HSA-1483166
Acyl chain remodelling of PEREACTOMER-HSA-1482839
Acyl chain remodelling of PCREACTOMER-HSA-1482788
Acyl chain remodelling of PSREACTOMER-HSA-1482801
Acyl chain remodelling of PIREACTOMER-HSA-1482922
Acyl chain remodelling of PGREACTOMER-HSA-1482925

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
387030302024PLA2G12A protects against diet-induced obesity and insulin resistance by enhancing energy expenditure and clearance of circulating triglycerides.0
387030302024PLA2G12A protects against diet-induced obesity and insulin resistance by enhancing energy expenditure and clearance of circulating triglycerides.0
295277192018Association between PLA2G12A polymorphism and patients with schizophrenia in a southern Chinese Han population.0
295277192018Association between PLA2G12A polymorphism and patients with schizophrenia in a southern Chinese Han population.0
274340782016Association between PLA2G12A Polymorphisms and Schizophrenia in a Han Chinese Population from Northeast China.5
274340782016Association between PLA2G12A Polymorphisms and Schizophrenia in a Han Chinese Population from Northeast China.5
203320992010A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts.8
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.15
203320992010A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts.8
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.15
197732792009Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity.9
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.105
197732792009Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity.9
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.105
125221022003Cellular arachidonate-releasing function of novel classes of secretory phospholipase A2s (groups III and XII).30

Citation

Dessen P

PLA2G12A (phospholipase A2 group XIIA)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/71950/pla2g12a-(phospholipase-a2-group-xiia)